Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes

• Main Authors: Pan W.-C., Kile M.L., Seow W.J., Lin X., Quamruzzaman Q., Rahman M., Mahiuddin G., Mostofa G., Lu Q., Christiani D.C.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2019
• Subjects: arsenic; drinking water; hemoglobin A1c; Adamts9 gene; adult; article; Bangladesh; case control study; controlled study; disease association; drug induced disease; female; follow up; gene; gene locus; genetic susceptibility; genetic variability; genotype environment interaction; hemoglobin blood level; human; logistic regression analysis; major clinical study; male; marker gene; molecular mechanics; non insulin dependent diabetes mellitus; Notch2 gene; risk assessment; single nucleotide polymorphism; skin defect; water contamination; Adult; Arsenic; Diabetes Mellitus, Type 2; Drinking Water; Environmental Exposure; Female; Gene-Environment Interaction; Genetic Loci; Genetic Predisposition to Disease; Humans; Male; Polymorphism, Single Nucleotide; Receptor, Notch2; Water Pollutants, Chemical
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161278
• Institution: National University of Singapore

10.1371/journal.pone.0070792