Bivariate Genome-Wide Association Analyses Identified Genes with Pleiotropic Effects for Femoral Neck Bone Geometry and Age at Menarche

• Main Authors: Ran S., Pei Y.-F., Liu Y.-J., Zhang L., Han Y.-Y., Hai R., Tian Q., Lin Y., Yang T.-L., Guo Y.-F., Shen H., Thethi I.S., Zhu X.-Z., Deng H.-W.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: genomic DNA; iduronate 2 sulfatase; adult; article; buckling ratio; Caucasian; Chinese; controlled study; cortical thickness (bone); cross sectional area; female; femoral neck geometric parameters; fracture; gene; gene identification; gene location; genetic analysis; genetic association; genetic regulation; human; IDS gene; LOC148145 gene; menarche; musculoskeletal system parameters; Nrcam gene; osteoporosis; pathophysiology; periosteal diameter; pleiotropy; replication study; risk assessment; section modulus; single nucleotide polymorphism; United States; Adult; Age Factors; Aged; Asian Continental Ancestry Group; European Continental Ancestry Group; Female; Femur Neck; Genome-Wide Association Study; Genotype; Humans; Linkage Disequilibrium; Menarche; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161332
• Institution: National University of Singapore

10.1371/journal.pone.0060362