Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination.

• Main Authors: Lim G.G., Neurodegeneration Research Laboratory National Neuroscience Institute, Chew K.C., Ng X.H., Henry-Basil A., Sim R.W., Tan J.M., Chai C.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2019
• Subjects: carrier protein; lysine; nerve protein; parkin; proteasome; proteasome inhibitor; protein binding; SNCAIP protein, human; UBE2N protein, human; ubiquitin conjugating enzyme; ubiquitin protein ligase; autophagy; drug effects; genetics; HEK293 cell line; homeostasis; human; metabolism; mutation; protein degradation; protein transport; ubiquitination; Autophagy; Carrier Proteins; HEK293 Cells; Homeostasis; Humans; Lysine; Mutation; Nerve Tissue Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Transport; Proteolysis; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161353
• Institution: National University of Singapore

10.1371/journal.pone.0073235