Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2

10.1371/journal.pone.0104914

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Main Authors:	Chee S.M.Q., Wongsantichon J., Soo Tng Q., Robinson R., Joseph T.L., Verma C., Lane D.P., Brown C.J., Ghadessy F.J.
Other Authors:	BIOLOGY (NU)
Format:	Article
Published:	2019
Subjects:	imidazole derivative MDM2 protein, human nutlin 3 peptide piperazine derivative protein binding protein MDM2 protein p53 recombinant protein amino acid sequence antagonists and inhibitors binding competition cell line chemical structure chemistry fluorescence polarization genetics human metabolism molecular dynamics molecular genetics protein conformation protein domain site directed mutagenesis X ray crystallography Amino Acid Sequence Binding, Competitive Cell Line Crystallography, X-Ray Fluorescence Polarization Humans Imidazoles Models, Molecular Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Peptides Piperazines Protein Binding Protein Conformation Protein Interaction Domains and Motifs Proto-Oncogene Proteins c-mdm2 Recombinant Proteins Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161389
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1613892024-04-24T05:47:52Z Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2 Chee S.M.Q. Wongsantichon J. Soo Tng Q. Robinson R. Joseph T.L. Verma C. Lane D.P. Brown C.J. Ghadessy F.J. BIOLOGY (NU) BIOCHEMISTRY CHEMICAL & BIOMOLECULAR ENGINEERING MEDICINE imidazole derivative MDM2 protein, human nutlin 3 peptide piperazine derivative protein binding protein MDM2 protein p53 recombinant protein amino acid sequence antagonists and inhibitors binding competition cell line chemical structure chemistry fluorescence polarization genetics human metabolism molecular dynamics molecular genetics protein conformation protein domain site directed mutagenesis X ray crystallography Amino Acid Sequence Binding, Competitive Cell Line Crystallography, X-Ray Fluorescence Polarization Humans Imidazoles Models, Molecular Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Peptides Piperazines Protein Binding Protein Conformation Protein Interaction Domains and Motifs Proto-Oncogene Proteins c-mdm2 Recombinant Proteins Tumor Suppressor Protein p53 10.1371/journal.pone.0104914 PLoS ONE 9 8 e104914 2019-11-05T00:33:45Z 2019-11-05T00:33:45Z 2014 Article Chee S.M.Q., Wongsantichon J., Soo Tng Q., Robinson R., Joseph T.L., Verma C., Lane D.P., Brown C.J., Ghadessy F.J. (2014). Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2. PLoS ONE 9 (8) : e104914. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0104914 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161389 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	imidazole derivative MDM2 protein, human nutlin 3 peptide piperazine derivative protein binding protein MDM2 protein p53 recombinant protein amino acid sequence antagonists and inhibitors binding competition cell line chemical structure chemistry fluorescence polarization genetics human metabolism molecular dynamics molecular genetics protein conformation protein domain site directed mutagenesis X ray crystallography Amino Acid Sequence Binding, Competitive Cell Line Crystallography, X-Ray Fluorescence Polarization Humans Imidazoles Models, Molecular Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Peptides Piperazines Protein Binding Protein Conformation Protein Interaction Domains and Motifs Proto-Oncogene Proteins c-mdm2 Recombinant Proteins Tumor Suppressor Protein p53
spellingShingle	imidazole derivative MDM2 protein, human nutlin 3 peptide piperazine derivative protein binding protein MDM2 protein p53 recombinant protein amino acid sequence antagonists and inhibitors binding competition cell line chemical structure chemistry fluorescence polarization genetics human metabolism molecular dynamics molecular genetics protein conformation protein domain site directed mutagenesis X ray crystallography Amino Acid Sequence Binding, Competitive Cell Line Crystallography, X-Ray Fluorescence Polarization Humans Imidazoles Models, Molecular Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Peptides Piperazines Protein Binding Protein Conformation Protein Interaction Domains and Motifs Proto-Oncogene Proteins c-mdm2 Recombinant Proteins Tumor Suppressor Protein p53 Chee S.M.Q. Wongsantichon J. Soo Tng Q. Robinson R. Joseph T.L. Verma C. Lane D.P. Brown C.J. Ghadessy F.J. Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
description	10.1371/journal.pone.0104914
author2	BIOLOGY (NU)
author_facet	BIOLOGY (NU) Chee S.M.Q. Wongsantichon J. Soo Tng Q. Robinson R. Joseph T.L. Verma C. Lane D.P. Brown C.J. Ghadessy F.J.
format	Article
author	Chee S.M.Q. Wongsantichon J. Soo Tng Q. Robinson R. Joseph T.L. Verma C. Lane D.P. Brown C.J. Ghadessy F.J.
author_sort	Chee S.M.Q.
title	Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
title_short	Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
title_full	Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
title_fullStr	Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
title_full_unstemmed	Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2
title_sort	structure of a stapled peptide antagonist bound to nutlin-resistant mdm2
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161389
_version_	1800913791832031232

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2

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