A systemic evaluation of cardiac differentiation from mRNA reprogrammed human induced pluripotent stem cells

• Main Authors: Mehta A., Verma V., Nandihalli M., Ramachandra C.J.A., Sequiera G.L., Sudibyo Y., Chung Y., Sun W., Shim W.
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: 2019
• Subjects: 1 [2 (6 methyl 2 pyridyl)ethyl] 4 (4 methylsulfonylaminobenzoyl)piperidine; adrenergic receptor; calcium channel; isoprenaline; messenger RNA; nifedipine; potassium channel; sodium channel; sodium ion; sotalol; tetrodotoxin; carbachol; cardiotonic agent; cholinergic receptor stimulating agent; ion channel; octamer transcription factor 4; stage specific embryo antigen; stage-specific embryonic antigen-4; adult; animal experiment; animal tissue; article; cell differentiation; controlled study; gene expression; heart; heart contraction; heart muscle cell; human; human cell; in vitro study; male; mesoderm; middle aged; mouse; nonhuman; nuclear reprogramming; pluripotent stem cell; QT prolongation; skin fibroblast; sodium transport; tissue differentiation; cell culture; cell reprogramming technique; confocal microscopy; cytology; drug effects; evaluation study; fibroblast; genetics; membrane potential; metabolism; physiology; procedures; reverse transcription polymerase chain reaction; Carbachol; Cardiotonic Agents; Cell Differentiation; Cells, Cultured; Cellular Reprogramming; Cellular Reprogramming Techniques; Cholinergic Agonists; Fibroblasts; Gene Expression; Humans; Induced Pluripotent Stem Cells; Ion Channels; Isoproterenol; Male; Membrane Potentials; Microscopy, Confocal; Middle Aged; Myocytes, Cardiac; Octamer Transcription Factor-3; Pluripotent Stem Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stage-Specific Embryonic Antigens
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161396
• Institution: National University of Singapore

10.1371/journal.pone.0103485