O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes

10.1371/journal.pone.0089124

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Main Authors:	Kapoor R., Singh S., Tripathi M., Bhatnagar P., Kakkar P., Gupta K.C.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	berberine caspase 3 caspase 9 dextran glucose nanoparticle o hexadecyl dextran phosphatidylserine protein Bax protein bcl 2 unclassified drug DNA glutathione nitric oxide O-hexadecyl-dextran reactive oxygen metabolite superoxide dismutase animal cell antioxidant activity apoptosis article cell cycle G1 phase cell membrane depolarization cell protection cell stress cell viability concentration (parameters) controlled study drug efficacy enzyme activation glucose stress lipid peroxidation liver cell male mitochondrial membrane potential nonhuman oxidative stress rat animal chemistry dose response drug effects metabolism mitochondrion particle size secretion (process) transport at the cellular level Animals Apoptosis Berberine Biological Transport Cytoprotection Dextrans Dose-Response Relationship, Drug Glucose Glutathione Lipid Peroxidation Male Mitochondria Nanoparticles Nitric Oxide Oxidative Stress Particle Size Proto-Oncogene Proteins c-bcl-2 Rats Reactive Oxygen Species Superoxide Dismutase
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161429
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614292023-11-01T07:27:28Z O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes Kapoor R. Singh S. Tripathi M. Bhatnagar P. Kakkar P. Gupta K.C. DUKE-NUS MEDICAL SCHOOL berberine caspase 3 caspase 9 dextran glucose nanoparticle o hexadecyl dextran phosphatidylserine protein Bax protein bcl 2 unclassified drug berberine dextran DNA glucose glutathione nitric oxide O-hexadecyl-dextran protein bcl 2 reactive oxygen metabolite superoxide dismutase animal cell antioxidant activity apoptosis article cell cycle G1 phase cell membrane depolarization cell protection cell stress cell viability concentration (parameters) controlled study drug efficacy enzyme activation glucose stress lipid peroxidation liver cell male mitochondrial membrane potential nonhuman oxidative stress rat animal apoptosis chemistry dose response drug effects metabolism mitochondrion oxidative stress particle size secretion (process) transport at the cellular level Animals Apoptosis Berberine Biological Transport Cytoprotection Dextrans DNA Dose-Response Relationship, Drug Glucose Glutathione Lipid Peroxidation Male Mitochondria Nanoparticles Nitric Oxide Oxidative Stress Particle Size Proto-Oncogene Proteins c-bcl-2 Rats Reactive Oxygen Species Superoxide Dismutase 10.1371/journal.pone.0089124 PLoS ONE 9 2 e89124 2019-11-05T02:03:30Z 2019-11-05T02:03:30Z 2014 Article Kapoor R., Singh S., Tripathi M., Bhatnagar P., Kakkar P., Gupta K.C. (2014). O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes. PLoS ONE 9 (2) : e89124. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0089124 1932-6203 https://scholarbank.nus.edu.sg/handle/10635/161429 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	berberine caspase 3 caspase 9 dextran glucose nanoparticle o hexadecyl dextran phosphatidylserine protein Bax protein bcl 2 unclassified drug berberine dextran DNA glucose glutathione nitric oxide O-hexadecyl-dextran protein bcl 2 reactive oxygen metabolite superoxide dismutase animal cell antioxidant activity apoptosis article cell cycle G1 phase cell membrane depolarization cell protection cell stress cell viability concentration (parameters) controlled study drug efficacy enzyme activation glucose stress lipid peroxidation liver cell male mitochondrial membrane potential nonhuman oxidative stress rat animal apoptosis chemistry dose response drug effects metabolism mitochondrion oxidative stress particle size secretion (process) transport at the cellular level Animals Apoptosis Berberine Biological Transport Cytoprotection Dextrans DNA Dose-Response Relationship, Drug Glucose Glutathione Lipid Peroxidation Male Mitochondria Nanoparticles Nitric Oxide Oxidative Stress Particle Size Proto-Oncogene Proteins c-bcl-2 Rats Reactive Oxygen Species Superoxide Dismutase
spellingShingle	berberine caspase 3 caspase 9 dextran glucose nanoparticle o hexadecyl dextran phosphatidylserine protein Bax protein bcl 2 unclassified drug berberine dextran DNA glucose glutathione nitric oxide O-hexadecyl-dextran protein bcl 2 reactive oxygen metabolite superoxide dismutase animal cell antioxidant activity apoptosis article cell cycle G1 phase cell membrane depolarization cell protection cell stress cell viability concentration (parameters) controlled study drug efficacy enzyme activation glucose stress lipid peroxidation liver cell male mitochondrial membrane potential nonhuman oxidative stress rat animal apoptosis chemistry dose response drug effects metabolism mitochondrion oxidative stress particle size secretion (process) transport at the cellular level Animals Apoptosis Berberine Biological Transport Cytoprotection Dextrans DNA Dose-Response Relationship, Drug Glucose Glutathione Lipid Peroxidation Male Mitochondria Nanoparticles Nitric Oxide Oxidative Stress Particle Size Proto-Oncogene Proteins c-bcl-2 Rats Reactive Oxygen Species Superoxide Dismutase Kapoor R. Singh S. Tripathi M. Bhatnagar P. Kakkar P. Gupta K.C. O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
description	10.1371/journal.pone.0089124
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Kapoor R. Singh S. Tripathi M. Bhatnagar P. Kakkar P. Gupta K.C.
format	Article
author	Kapoor R. Singh S. Tripathi M. Bhatnagar P. Kakkar P. Gupta K.C.
author_sort	Kapoor R.
title	O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
title_short	O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
title_full	O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
title_fullStr	O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
title_full_unstemmed	O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
title_sort	o-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161429
_version_	1781791759925248000

O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes

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