Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G

• Main Authors: Ogata S., Shimizu C., Franco A., Touma R., Kanegaye J.T., Choudhury B.P., Naidu N.N., Kanda Y., Hoang L.T., Hibberd M.L., Tremoulet A.H., Varki A., Burns J.C.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2019
• Subjects: acetylsalicylic acid; beta galactoside a2 6 sialyltransferase I; immunoglobulin G; sialyltransferase; unclassified drug; article; blood; cell lysate; child; controlled study; disease association; enzyme blood level; enzyme linked immunosorbent assay; female; gene expression; human; human cell; major clinical study; male; mucocutaneous lymph node syndrome; protein blood level; quantitative analysis; reverse transcription polymerase chain reaction; sialylation; treatment failure; treatment response; B-Lymphocytes; Case-Control Studies; Cell Line; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Fucose; Galactose; Glycosylation; Humans; Immunoglobulins, Intravenous; Male; Mucocutaneous Lymph Node Syndrome; N-Acetylneuraminic Acid; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Sialyltransferases; Solubility; Treatment Outcome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161449
• Institution: National University of Singapore

10.1371/journal.pone.0081448