Enhanced Neutralizing Antibody Titers and Th1 Polarization from a Novel Escherichia coli Derived Pandemic Influenza Vaccine

• Main Authors: Skibinski D.A.G., Hanson B.J., Lin Y., von Messling V., Jegerlehner A., Tee J.B.S., Chye D.H., Wong S.K.K., Ng A.A.P., Lee H.Y., Au B., Lee B.T.K., Santoso L., Poidinger M., Fairhurst A.-M., Matter A., Bachmann M.F., Saudan P., Connolly J.E.
• Other Authors: BIOLOGY (NU)
• Format: Article
• Published: 2019
• Subjects: adjuvant; aluminum potassium sulfate; gamma interferon; hemagglutinin; immunoglobulin G2a antibody; influenza vaccine; neutralizing antibody; 2009 H1N1 influenza; animal experiment; animal model; animal tissue; antibody production; antibody titer; antigen specificity; article; bacteriophage; cellular immunity; covalent bond; cross linking; cytokine production; drug formulation; Escherichia coli; immunization; immunomodulation; mouse; nonhuman; protein domain; spleen cell; Th1 cell; virus like agent; virus load; Adjuvants, Immunologic; Alum Compounds; Animals; Antibodies, Neutralizing; Antibodies, Viral; Antibody Specificity; Bacteriophages; Female; Ferrets; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Immunoglobulin G; Influenza A Virus, H1N1 Subtype; Influenza Vaccines; Interferon-gamma; Mice; Orthomyxoviridae Infections; RNA, Bacterial; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets; Th1 Cells; Vaccines, Virus-Like Particle
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161461
• Institution: National University of Singapore

10.1371/journal.pone.0076571