Mucosal Vaccination with Recombinant Adenovirus Encoding Nucleoprotein Provides Potent Protection against Influenza Virus Infection

• Main Authors: Kim S.-H., Kim J.Y., Choi Y., Nguyen H.H., Song M.K., Chang J.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: epitope; Hermes antigen; immunoglobulin A; immunoglobulin G; influenza vaccine; recombinant Adenovirus encoding nucleoprotein; unclassified drug; virus nucleoprotein; animal experiment; animal model; article; CD8+ T lymphocyte; controlled study; cross reaction; cytotoxic T lymphocyte; drug dose comparison; drug efficacy; drug potency; drug targeting; female; human; human cell; humoral immunity; infection prevention; influenza A; influenza vaccination; Influenza virus A; innate immunity; mortality; mouse; mucosa; nonhuman; survival; virus replication; weight reduction; Adenoviridae; Administration, Mucosal; Animals; Bronchoalveolar Lavage Fluid; CD8-Positive T-Lymphocytes; DNA Primers; Enzyme-Linked Immunosorbent Assay; HEK293 Cells; Humans; Immunoglobulin A; Influenza Vaccines; Influenza, Human; Mice; Mice, Inbred BALB C; Nucleoproteins; Vaccines, Synthetic
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161464
• Institution: National University of Singapore

10.1371/journal.pone.0075460