Localization of HPV-18 E2 at Mitochondrial Membranes Induces ROS Release and Modulates Host Cell Metabolism

• Main Authors: Lai D., Tan C.L., Gunaratne J., Quek L.S., Nei W., Thierry F., Bellanger S.
• Other Authors: ANATOMY
• Format: Article
• Published: 2019
• Subjects: hypoxia inducible factor 1alpha; membrane protein; protein E2; reactive oxygen metabolite; unclassified drug; virus protein; apoptosis; article; cell culture; cell fractionation; cell isolation; cell metabolism; cell nucleus; controlled study; cytoplasm; electron microscopy; flow cytometry; genetic transfection; glycolysis; host cell; human; human cell; Human papillomavirus type 18; immunofluorescence; immunohistochemistry; immunoprecipitation; keratinocyte; mass spectrometry; mitochondrial membrane; nonhuman; papillomavirus infection; protein localization; respiratory chain; Western blotting; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Glycolysis; Human papillomavirus 18; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mitochondria; Mitochondrial Membranes; Oncogene Proteins, Viral; Reactive Oxygen Species; Viral Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161465
• Institution: National University of Singapore

10.1371/journal.pone.0075625