Human mesenchymal stem cells retain multilineage differentiation capacity including neural marker expression after extended in vitro expansion

• Main Authors: Okolicsanyi R.K., Camilleri E.T., Oikari L.E., Yu C., Cool S.M., Van Wijnen A.J., Griffiths L.R., Haupt L.M.
• Other Authors: ORTHOPAEDIC SURGERY
• Format: Article
• Published: 2019
• Subjects: 5' nucleotidase; beta1 integrin; CD146 antigen; CD200 antigen; CD24 antigen; CD45 antigen; CD56 antigen; endoglin; Hermes antigen; kruppel like factor 4; Thy 1 antigen; transcription factor HES 1; transcription factor PAX3; transcription factor PAX9; transcription factor Sox5; transcription factor Sox6; transcription factor Sox9; biological marker; transcription factor; adipocyte; adipogenesis; adult; Article; bone development; cell differentiation; cell expansion; cell growth; cell lineage; controlled study; female; fluorescence activated cell sorting; gene expression; human; human cell; immunocytochemistry; in vitro study; male; mesenchymal stem cell; neural stem cell; osteoblast; polymerase chain reaction; protein expression; quantitative analysis; stem cell culture; young adult; cell culture; cell membrane; cell proliferation; cell shape; cytology; flow cytometry; gene expression profiling; gene expression regulation; mesenchymal stroma cell; metabolism; multicellular spheroid; nerve cell; Western blotting; Adipogenesis; Antigens, CD45; Biomarkers; Blotting, Western; Cell Differentiation; Cell Lineage; Cell Membrane; Cell Proliferation; Cell Shape; Cells, Cultured; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Humans; Mesenchymal Stromal Cells; Neurons; Osteogenesis; Spheroids, Cellular; Transcription Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161489
• Institution: National University of Singapore

10.1371/journal.pone.0137255