Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks

10.1371/journal.pone.0135958

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Main Authors:	Vidyasekar P., Shyamsunder P., Arun R., Santhakumar R., Kapadia N.K., Kumar R., Verma R.S.
Other Authors:	CANCER SCIENCE INSTITUTE OF SINGAPORE
Format:	Article
Published:	2019
Subjects:	cyclin A2 cyclin dependent kinase 6 microRNA microRNA 22 transcription factor Sp1 tumor marker cell cycle protein oncoprotein apoptosis Article cancer growth cancer prognosis CCNA2 gene CDK6 gene cell activity cell cycle regulation cell population cell proliferation cell structure cell transformation cell viability colony formation colorectal cancer cell line controlled study DLD 1 cell line DNA microarray down regulation gene control gene expression profiling gene ontology gene silencing gene targeting genome analysis leukemia cell line microgravity MIR17HG gene MIR21HG gene MIR22HG gene MOLT 4 cell line oncogene proto oncogene regulatory mechanism simulation SP1 gene transcription regulation tumor suppressor gene upregulation cell cycle gene expression regulation gene regulatory network genetics genome-wide association study human human genome metabolism signal transduction tumor cell line weightlessness Cell Cycle Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genome, Human Genome-Wide Association Study Humans MicroRNAs Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins Signal Transduction Weightlessness Simulation
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161491
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1614912023-10-31T09:19:04Z Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks Vidyasekar P. Shyamsunder P. Arun R. Santhakumar R. Kapadia N.K. Kumar R. Verma R.S. CANCER SCIENCE INSTITUTE OF SINGAPORE cyclin A2 cyclin dependent kinase 6 microRNA microRNA 22 transcription factor Sp1 tumor marker cell cycle protein oncoprotein apoptosis Article cancer growth cancer prognosis CCNA2 gene CDK6 gene cell activity cell cycle regulation cell population cell proliferation cell structure cell transformation cell viability colony formation colorectal cancer cell line controlled study DLD 1 cell line DNA microarray down regulation gene control gene expression profiling gene ontology gene silencing gene targeting genome analysis leukemia cell line microgravity MIR17HG gene MIR21HG gene MIR22HG gene MOLT 4 cell line oncogene proto oncogene regulatory mechanism simulation SP1 gene transcription regulation tumor suppressor gene upregulation cell cycle gene expression profiling gene expression regulation gene regulatory network genetics genome-wide association study human human genome metabolism signal transduction tumor cell line weightlessness Cell Cycle Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genome, Human Genome-Wide Association Study Humans MicroRNAs Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins Signal Transduction Weightlessness Simulation 10.1371/journal.pone.0135958 PLoS ONE 10 8 e0135958 2019-11-06T01:27:26Z 2019-11-06T01:27:26Z 2015 Article Vidyasekar P., Shyamsunder P., Arun R., Santhakumar R., Kapadia N.K., Kumar R., Verma R.S. (2015). Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks. PLoS ONE 10 (8) : e0135958. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0135958 19326203 https://scholarbank.nus.edu.sg/handle/10635/161491 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	cyclin A2 cyclin dependent kinase 6 microRNA microRNA 22 transcription factor Sp1 tumor marker cell cycle protein oncoprotein apoptosis Article cancer growth cancer prognosis CCNA2 gene CDK6 gene cell activity cell cycle regulation cell population cell proliferation cell structure cell transformation cell viability colony formation colorectal cancer cell line controlled study DLD 1 cell line DNA microarray down regulation gene control gene expression profiling gene ontology gene silencing gene targeting genome analysis leukemia cell line microgravity MIR17HG gene MIR21HG gene MIR22HG gene MOLT 4 cell line oncogene proto oncogene regulatory mechanism simulation SP1 gene transcription regulation tumor suppressor gene upregulation cell cycle gene expression profiling gene expression regulation gene regulatory network genetics genome-wide association study human human genome metabolism signal transduction tumor cell line weightlessness Cell Cycle Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genome, Human Genome-Wide Association Study Humans MicroRNAs Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins Signal Transduction Weightlessness Simulation
spellingShingle	cyclin A2 cyclin dependent kinase 6 microRNA microRNA 22 transcription factor Sp1 tumor marker cell cycle protein oncoprotein apoptosis Article cancer growth cancer prognosis CCNA2 gene CDK6 gene cell activity cell cycle regulation cell population cell proliferation cell structure cell transformation cell viability colony formation colorectal cancer cell line controlled study DLD 1 cell line DNA microarray down regulation gene control gene expression profiling gene ontology gene silencing gene targeting genome analysis leukemia cell line microgravity MIR17HG gene MIR21HG gene MIR22HG gene MOLT 4 cell line oncogene proto oncogene regulatory mechanism simulation SP1 gene transcription regulation tumor suppressor gene upregulation cell cycle gene expression profiling gene expression regulation gene regulatory network genetics genome-wide association study human human genome metabolism signal transduction tumor cell line weightlessness Cell Cycle Cell Cycle Proteins Cell Line, Tumor Cell Proliferation Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genome, Human Genome-Wide Association Study Humans MicroRNAs Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins Signal Transduction Weightlessness Simulation Vidyasekar P. Shyamsunder P. Arun R. Santhakumar R. Kapadia N.K. Kumar R. Verma R.S. Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
description	10.1371/journal.pone.0135958
author2	CANCER SCIENCE INSTITUTE OF SINGAPORE
author_facet	CANCER SCIENCE INSTITUTE OF SINGAPORE Vidyasekar P. Shyamsunder P. Arun R. Santhakumar R. Kapadia N.K. Kumar R. Verma R.S.
format	Article
author	Vidyasekar P. Shyamsunder P. Arun R. Santhakumar R. Kapadia N.K. Kumar R. Verma R.S.
author_sort	Vidyasekar P.
title	Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
title_short	Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
title_full	Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
title_fullStr	Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
title_full_unstemmed	Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
title_sort	genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and microrna gene networks
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161491
_version_	1781791773037690880

Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks

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