Association of ABCB1 and FLT3 polymorphisms with toxicities and survival in asian patients receiving sunitinib for renal cell carcinoma

• Main Authors: Chu Y.-H., Li H., Tan H.S., Koh V., Lai J., Phyo W.M., Choudhury Y., Kanesvaran R., Chau N.M., Toh C.K., Ng Q.S., Tan P.H., Chowbay B., Tan M.-H.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: BIM protein; breast cancer resistance protein; CD135 antigen; multidrug resistance protein 1; sunitinib; tumor marker; vasculotropin receptor 2; ABCB1 protein, human; antineoplastic agent; FLT3 protein, human; indole derivative; multidrug resistance protein; pyrrole derivative; ABCB1 gene; ABCG2 gene; adult; allele; Article; Asian; BIM gene; cancer survival; Caucasian; comorbidity; controlled study; drug safety; ethnicity; female; FLT3 gene; gene frequency; genetic association; genetic marker; genetic polymorphism; hand foot syndrome; haplotype; human; kidney carcinoma; leukopenia; liver toxicity; major clinical study; male; multiple cycle treatment; neutropenia; prediction; progression free survival; thrombocytopenia; validation process; VEGFR2 gene; adolescent; adverse drug reaction; aged; Asian continental ancestry group; Carcinoma, Renal Cell; disease free survival; ethnology; genetic predisposition; genetics; genotype; Kidney Neoplasms; metastasis; middle aged; Singapore; single nucleotide polymorphism; treatment outcome; young adult; Adolescent; Adult; Aged; Antineoplastic Agents; Asian Continental Ancestry Group; Disease-Free Survival; Drug-Related Side Effects and Adverse Reactions; Female; fms-Like Tyrosine Kinase 3; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Indoles; Male; Middle Aged; Neoplasm Metastasis; P-Glycoproteins; Polymorphism, Single Nucleotide; Pyrroles; Treatment Outcome; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161494
• Institution: National University of Singapore

10.1371/journal.pone.0134102