The Cdc42 effector kinase PAK4 localizes to cell-cell junctions and contributes to establishing cell polarity

• Main Authors: Selamat W., Tay P.-L.F., Baskaran Y., Manser E.
• Other Authors: PHARMACOLOGY
• Format: Article
• Published: 2019
• Subjects: beta catenin; p21 activated kinase 4; protein Cdc42; protein serine threonine kinase inhibitor; serine; CTNNB1 protein, human; p21 activated kinase; PAK4 protein, human; PF 3758309; protein kinase inhibitor; pyrazole derivative; pyrrole derivative; animal cell; Article; cell junction; cell migration; cell polarity; centrosome; complex formation; focal adhesion; human; human cell; MCF 7 cell line; monolayer culture; nonhuman; protein assembly; protein depletion; protein localization; protein phosphorylation; U2OS cell line; wound; antagonists and inhibitors; drug effects; gene silencing; genetics; MCF-7 cell line; metabolism; phosphorylation; tumor cell line; beta Catenin; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Polarity; Gene Knockdown Techniques; Humans; Intercellular Junctions; MCF-7 Cells; p21-Activated Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyrazoles; Pyrroles; Serine
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161506
• Institution: National University of Singapore

10.1371/journal.pone.0129634