Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility

• Main Authors: Kim J., Shimizu C., Kingsmore S.F., Veeraraghavan N., Levy E., Dos Santos A.M.R., Yang H., Flatley J., Hoang L.T., Hibberd M.L., Tremoulet A.H., Harismendy O., Ohno-Machado L., Burns J.C.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: interleukin 6; toll like receptor 6; transcriptome; MEF2A protein, human; myocyte enhancer factor 2; TLR6 protein, human; African American; Article; child; clinical article; controlled study; disease predisposition; erythrocyte sedimentation rate; family; female; gene frequency; gene linkage disequilibrium; genome-wide association study; genotype; heterozygosity; homozygosity; human; male; mucocutaneous lymph node syndrome; pattern recognition; quantitative trait locus; signal transduction; whole genome sequencing; genetic predisposition; genetics; human genome; single nucleotide polymorphism; African Americans; Female; Gene Frequency; Genetic Predisposition to Disease; Genome, Human; Genome-Wide Association Study; Humans; Male; MEF2 Transcription Factors; Mucocutaneous Lymph Node Syndrome; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Toll-Like Receptor 6
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161532
• Institution: National University of Singapore

10.1371/journal.pone.0170977