Peripheral immune cell populations associated with cognitive deficits and negative symptoms of treatment-resistant schizophrenia

• Main Authors: Fernandez-Egea E., Vértes P.E., Flint S.M., Turner L., Mustafa S., Hatton A., Smith K.G.C., Lyons P.A., Bullmore E.T.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: biological marker; chemokine receptor CXCR5; clozapine; dopamine 3 receptor; dopamine receptor; HLA DR antigen; risperidone; DRD3 protein, human; neuroleptic agent; adult; Article; B lymphocyte; case control study; CD4+ T lymphocyte; cell activation; cell population; clinical article; cognitive defect; controlled study; cross-sectional study; dopaminergic transmission; female; flow cytometry; gene expression; human; immunocompetent cell; immunophenotyping; male; memory T lymphocyte; mental patient; monocyte; natural killer cell; negative syndrome; receptor gene; regulatory T lymphocyte; schizophrenia; venous blood; biosynthesis; blood; CD4 lymphocyte count; Cognitive Dysfunction; cytology; dendritic cell; genetics; immunological memory; immunology; lymphocyte activation; middle aged; T lymphocyte subpopulation; young adult; Adult; Antipsychotic Agents; Biomarkers; Case-Control Studies; CD4 Lymphocyte Count; Clozapine; Cross-Sectional Studies; Dendritic Cells; Female; Flow Cytometry; HLA-DR Antigens; Humans; Immunologic Memory; Killer Cells, Natural; Lymphocyte Activation; Male; Middle Aged; Receptors, Dopamine D3; Schizophrenia; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161568
• Institution: National University of Singapore

10.1371/journal.pone.0155631