Cytochrome P4501A2 metabolizes 17?-estradiol to suppress hepatocellular carcinoma

• Main Authors: Ren J., Chen G.G., Liu Y., Su X., Hu B., Leung B.C.S., Wang Y., Ho R.L.K., Yang S., Lu G., Lee C.G., Lai P.B.S.
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2019
• Subjects: 2 methoxyestradiol; catechol methyltransferase; cytochrome P450 1A2; cytochrome P450 3A4; estradiol; protein p53; sorafenib; 2-methoxyestradiol; carbanilamide derivative; CYP1A2 protein, human; estrogen; estrogen receptor; estrogen receptor alpha; estrogen receptor beta; nicotinamide; animal experiment; animal model; animal tissue; apoptosis; Article; cancer growth; cancer incidence; cancer inhibition; cell proliferation; clinical article; concentration (parameters); controlled study; correlational study; cytotoxicity; female; hormone metabolism; human; human cell; human tissue; liver carcinogenesis; liver cell carcinoma; male; mouse; nonhuman; protein expression; protein function; protein protein interaction; sex difference; upregulation; analogs and derivatives; animal; Bagg albino mouse; Carcinoma, Hepatocellular; drug effects; liver; Liver Neoplasms; metabolism; nude mouse; tumor cell line; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1A2; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Humans; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Receptors, Estrogen; Tumor Suppressor Protein p53
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161572
• Institution: National University of Singapore

10.1371/journal.pone.0153863