Respiratory DC use IFITM3 to avoid direct viral infection and safeguard virus-specific CD8+ T cell priming

• Main Authors: Infusini G., Smith J.M., Yuan H., Pizzolla A., Ng W.C., Londrigan S.L., Haque A., Reading P.C., Villadangos J.A., Wakim L.M.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: interferon; interferon induced transmembrane protein 3; interferon regulatory factor 3; interferon regulatory factor 7; membrane protein; unclassified drug; virus antigen; fragilis protein, mouse; Irf3 protein, mouse; Irf7 protein, mouse; adaptive immunity; animal cell; Article; CD8+ T lymphocyte; controlled study; dendritic cell; draining lymph node; infection sensitivity; influenza; lymph node; lymphocyte function; lymphocyte migration; mouse; nonhuman; protein expression; protein transport; respiratory dendritic cell; respiratory system; signal transduction; T lymphocyte priming; upregulation; animal; cell culture; flow cytometry; genetics; immunology; knockout mouse; metabolism; orthomyxovirus infection; Western blotting; Animals; Blotting, Western; CD8-Positive T-Lymphocytes; Cells, Cultured; Dendritic Cells; Flow Cytometry; Interferon Regulatory Factor-3; Interferon Regulatory Factor-7; Membrane Proteins; Mice; Mice, Knockout; Orthomyxoviridae Infections
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161604
• Institution: National University of Singapore

10.1371/journal.pone.0143539