Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity

• Main Authors: Endoh M., Endo T.A., Endoh T., Isono K.-i., Sharif J., Ohara O., Toyoda T., Ito T., Eskeland R., Bickmore W.A., Vidal M., Bernstein B.E., Koseki H.
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2019
• Subjects: histone H2A; histone H2AK119u1; polycomb group protein; polycomb repressive complex 1; protein Ring1A; protein Ring1B; RING finger protein; unclassified drug; animal cell; article; catalysis; cell differentiation; cell identity; cellular parameters; chromatin; chromatin compaction; complex formation; developmental gene; embryonic stem cell; gene expression; gene function; gene identification; gene location; gene repression; gene silencing; genetic association; histone ubiquitination; human; human cell; mouse; nonhuman; nucleotide sequence; promoter region; protein binding; protein function; transcription regulation; Animals; Cell Line; Chromatin; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Mice; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 1; Transcription Factors; Ubiquitin-Protein Ligases; Ubiquitination
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161636
• Institution: National University of Singapore

10.1371/journal.pgen.1002774