Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants

• Main Authors: Lee C.Y., Kam Y.-W., Fric J., Malleret B., Koh E.G.L., Prakash C., Huang W., Lee W.W.L., Lin C., Lin R.T.P., Renia L., Wang C.-I., Ng L.F.P., Warter L.
• Other Authors: LIFE SCIENCES INSTITUTE
• Format: Article
• Published: 2019
• Subjects: neutralizing antibody; immunoglobulin M; monoclonal antibody; virus antibody; virus antigen; virus protein; article; Chikungunya alphavirus; controlled study; nonhuman; virus cell interaction; virus mutation; virus neutralization; virus resistance; virus transmission; Alphavirus infection; animal; cell strain HEK293; chronic disease; disease transmission; genetics; human; immune evasion; immunology; mouse; mouse mutant; mutation; pathogenicity; protein secondary structure; protein tertiary structure; Alphavirus; Animalia; Chikungunya virus; Primates; Alphavirus Infections; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Antigens, Viral; Chronic Disease; HEK293 Cells; Humans; Immune Evasion; Immunoglobulin M; Mice; Mice, Knockout; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Viral Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161646
• Institution: National University of Singapore

10.1371/journal.ppat.1002390