Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer

• Main Authors: Maxwell C.A., Benítez J., Gómez-Baldó L., Osorio A., Bonifaci N., Fernández-Ramires R., Costes S.V., Guinó E., Chen H., Evans G.J.R., Mohan P., Català I., Petit A., Aguilar H., Villanueva A., Aytes A., Serra-Musach J., Rennert G., Lejbkowicz F., Peterlongo P., Manoukian S., Peissel B., Ripamonti C.B., Bonanni B., Viel A., Allavena A., Bernard L., Radice P., Friedman E., Kaufman B., Laitman Y., Dubrovsky M., Milgrom R., Jakubowska A., Cybulski C., Gorski B., Jaworska K., Durda K., Sukiennicki G., Lubi?ski J., Shugart Y.Y., Domchek S.M., Letrero R., Weber B.L., Hogervorst F.B.L., Rookus M.A., Collee J.M., Devilee P., Ligtenberg M.J., van der Luijt R.B., Aalfs C.M., Waisfisz Q., Wijnen J., van Roozendaal C.E.P., HEBON Hereditary Breast and Ovarian Cancer Group, EMBRACE Centre for Cancer Genetic Epidemiology, Easton D.F., Peock S., Cook M., Oliver C., Frost D., Harrington P., Lalloo F., Eeles R., Izatt L., Chu C., Eccles D., Douglas F., Brewer C., Nevanlinna H., Heikkinen T., Couch F.J., Wang X., Lindor N.M., Godwin A.K., Caligo M.A., Lombardi G., Loman N., Karlsson P., Ehrencrona H., von Wachenfeldt A., SWE-BRCA Swedish Breast Cancer Study, Barkardottir R., Hamann U., Rashid M.U., Lasa A., Caldés T., Andrés R., Schmitt M., Assmann V., Stevens K., Offit K., Curado J., Tilgner H., Guigó R., Aiza G., Brunet J., Martrat G., Urruticoechea A., Blanco I., Tihomirova L., Goldgar D.E., Buys S., John E.M., Miron A., Southey M., Daly M.B., BCFR Breast Cancer Family Registry, Schmutzler R.K., Wappenschmidt B., Meindl A., Arnold N., Deissler H., Varon-Mateeva R., Sutter C., Niederacher D., Imyamitov E., Sinilnikova O.M., Stoppa-Lyonne D., Mazoyer S., Verny-Pierre C., Castera L., de Pauw A., Bignon Y.-J., Uhrhammer N., Peyrat J.-P., Vennin P., Ferrer S., Collonge-Rame M.-A., Mortemousque I., GEMO Study Collaborators GEMO Study, Spurdle A.B., Beesley J., Chen X., Healey S., Barcellos-Hoff M.H., Gruber S.B., Lázaro C., Capellá G., McGuffog L., Nathanson K.L., Chenevix-Trench G., Fleisch M.C., Moreno V., Pujana M.A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: BRCA1 protein; BRCA2 protein; cell protein; estrogen receptor; nuclear protein; protein AURKA; protein RHAMM; protein TPX2; unclassified drug; aurora kinase; BRCA1 protein, human; BRCA2 protein, human; Hermes antigen; hyaluronan mediated motility receptor; hyaluronan-mediated motility receptor; protein serine threonine kinase; scleroprotein; article; breast cancer; breast carcinogenesis; cancer risk; cell polarity; controlled study; epithelial apicobasal polarization; gene locus; gene mutation; genetic analysis; genetic variability; human; human cell; microtubule; molecular interaction; negative feedback; penetrance; protein analysis; protein function; breast; breast tumor; cytology; epithelium cell; female; genetic predisposition; genetics; genotype; HeLa cell; heterozygote; metabolism; pathology; physiology; tumor cell line; tumor suppressor gene; ultrastructure; Antigens, CD44; BRCA1 Protein; BRCA2 Protein; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Polarity; Epithelial Cells; Extracellular Matrix Proteins; Female; Genes, BRCA1; Genes, BRCA2; Genetic Predisposition to Disease; Genetic Variation; Genotype; HeLa Cells; Heterozygote; Humans; Microtubules; Protein-Serine-Threonine Kinases; Receptors, Estrogen
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161649
• Institution: National University of Singapore

10.1371/journal.pbio.1001199