The human papillomavirus e6 oncogene represses a cell adhesion pathway and disrupts focal adhesion through degradation of tap63? upon transformation

• Main Authors: Khalifa Y., Teissier S., Tan M.-K.M., Phan Q.T., Daynac M., Wong W.Q., Thierry F.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: 2019
• Subjects: protein E6; protein p63; E6 protein, Human papillomavirus type 16; isoprotein; oncoprotein; protein p53; repressor protein; TP53 protein, human; TP63 protein, human; transcription factor; tumor suppressor protein; UBE3A protein, human; ubiquitin protein ligase; article; cancer cell; cell adhesion; controlled study; down regulation; focal adhesion; gene expression; gene silencing; gene targeting; genetic transfection; Human papillomavirus type 16; Human papillomavirus type 18; protein degradation; uterine cervix carcinoma; genetics; HeLa cell; human; metabolism; squamous cell carcinoma; virology; virus cell transformation; Human papillomavirus; Carcinoma, Squamous Cell; Cell Adhesion; Cell Transformation, Viral; Focal Adhesions; HeLa Cells; Human papillomavirus 16; Humans; Oncogene Proteins, Viral; Protein Isoforms; Proteolysis; Repressor Proteins; Transcription Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161651
• Institution: National University of Singapore

10.1371/journal.ppat.1002256