Multidrug resistant 2009 a/h1n1 influenza clinical isolate with a neuraminidase i223r mutation retains its virulence and transmissibility in ferrets

• Main Authors: van der Vries E., Kroeze E.J., Stittelaar K.J., Linster M., van der Linden A., Schrauwen E.J.A., Leijten L.M., van Amerongen G., Schutten M., Kuiken T., Osterhaus A.D.M.E., Fouchier R.A.M., Boucher C.A.B., Herfst S.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: arginine; isoleucine; oseltamivir; peramivir; zanamivir; sialidase; 2009 H1N1 influenza; aerosol; animal cell; animal experiment; animal model; animal tissue; article; cell strain; cross resistance; ferret; in vitro study; Influenza virus A H1N1; inoculation; lung alveolitis; lung lesion; multidrug resistance; mutation; nonhuman; pathogenesis; virus isolation; virus mutant; virus replication; virus strain; virus transmission; virus virulence; weight reduction; animal; cell line; disease model; disease transmission; dog; enzymology; genetics; human; influenza; metabolism; orthomyxovirus infection; pandemic; pathogenicity; Animalia; Mustela; Orthomyxoviridae; Animals; Cell Line; Disease Models, Animal; Dogs; Drug Resistance, Multiple, Viral; Ferrets; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Mutation; Neuraminidase; Orthomyxoviridae Infections; Pandemics
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161653
• Institution: National University of Singapore

10.1371/journal.ppat.1002276