Structural optimization and de novo design of dengue virus entry inhibitory peptides

• Main Authors: Costin J.M., Jenwitheesuk E., Lok S.-M., Hunsperger E., Conrads K.A., Fontaine K.A., Rees C.R., Rossmann M.G., Isern S., Samudrala R., Michael S.F.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: antivirus agent; peptide 1OAN1; peptide DN57opt; unclassified drug; virus envelope protein; peptide; virus antibody; animal cell; antiviral activity; article; cell assay; concentration response; controlled study; cryoelectron microscopy; cytotoxicity test; Dengue virus 2; drug design; drug mechanism; drug protein binding; drug research; drug screening; drug structure; in vitro study; incubation time; interferometry; nonhuman; nucleotide sequence; process optimization; protein domain; structure activity relation; structure analysis; virus culture; virus entry; virus expression; virus inhibition; virus morphology; virus particle; virus strain; amino acid sequence; analysis of variance; animal; biology; blood; cell line; chemical structure; chemistry; Dengue virus; drug effect; genetics; human; Macaca; metabolism; methodology; molecular genetics; physiology; polymerase chain reaction; virus attachment; Amino Acid Sequence; Analysis of Variance; Animals; Antibodies, Viral; Cell Line; Computational Biology; Cryoelectron Microscopy; Dengue Virus; Humans; Interferometry; Macaca mulatta; Models, Molecular; Molecular Sequence Data; Peptides; Polymerase Chain Reaction; Viral Envelope Proteins; Virus Attachment; Virus Internalization
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161662
• Institution: National University of Singapore

10.1371/journal.pntd.0000721