Fumarase: A mitochondrial metabolic enzyme and a cytosolic/nuclear component of the dna damage response

• Main Authors: Yogev O., Singer E., Shaulian E., Goldberg M., Fox T.D., Pines O.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: fumarate hydratase; fumaric acid; hypoxia inducible factor; fumaric acid derivative; histone; hypoxia inducible factor 1alpha; isoenzyme; Saccharomyces cerevisiae protein; tumor suppressor protein; article; cancer cell culture; carcinogenesis; cell protection; controlled study; cytosol; DNA metabolism; double stranded DNA break; enzyme activity; fungal strain; gene construct; gene function; gene location; glucose metabolism; human; human cell; mitochondrion; molecular interaction; molecular recognition; tumor suppressor gene; yeast; cell nucleus; DNA damage; enzymology; gene silencing; genetics; HeLa cell; kidney tumor; leiomyomatosis; metabolism; Saccharomyces cerevisiae; Eukaryota; Cell Nucleus; Cytosol; DNA Damage; Fumarate Hydratase; Fumarates; Gene Knockdown Techniques; Hela Cells; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Kidney Neoplasms; Leiomyomatosis; Mitochondria; Saccharomyces cerevisiae Proteins; Tumor Suppressor Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161665
• Institution: National University of Singapore

10.1371/journal.pbio.1000328