Genetic association and expression studies indicate a role of Toll-like receptor 8 in pulmonary tuberculosis

• Main Authors: Davila S., Hibberd M.L., Dass R.H., Wong H.E.E., Sahiratmadja E., Bonnard C., Alisjahbana B., Szeszko J.S., Balabanova Y., Drobniewski F., Van Crevel R., Van De Vosse E., Nejentsev S., Ottenhoff T.H.M., Seielstad M.
• Other Authors: SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
• Format: Article
• Published: 2019
• Subjects: toll like receptor 8; messenger RNA; TLR8 protein, human; adolescent; adult; aged; article; controlled study; DNA polymorphism; female; gene expression; gene sequence; genetic analysis; genetic susceptibility; human; lung tuberculosis; major clinical study; male; Mycobacterium tuberculosis; nucleotide sequence; polymerase chain reaction; single nucleotide polymorphism; X chromosome; case control study; cell line; gene frequency; gene linkage disequilibrium; genetic predisposition; genetics; haplotype; immunology; Indonesia; metabolism; middle aged; sexual development; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Cell Line; Chromosomes, Human, X; Female; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; RNA, Messenger; Sex Characteristics; Toll-Like Receptor 8; Tuberculosis, Pulmonary
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161682
• Institution: National University of Singapore

10.1371/journal.pgen.1000218