Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis
10.1371/journal.pone.0116589
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sg-nus-scholar.10635-1617442024-11-13T04:14:06Z Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis Lee J. Daniels V. Sands Z.A. Lebon F. Shi J. Biggin P.C. Verma C. BIOLOGY carrier proteins and binding proteins etiracetam radioligand SV2A protein ucb 30889 unclassified drug anticonvulsive agent etiracetam membrane protein nerve protein piracetam protein binding SV2A protein, human amino acid sequence Article binding site controlled study drug protein binding drug structure human human cell hydrophobicity ligand binding molecular dynamics nonhuman protein conformation radioassay sequence alignment sequence analysis site directed mutagenesis structural homology analogs and derivatives chemistry genetics metabolism molecular genetics protein secondary structure sequence homology Mus Amino Acid Sequence Anticonvulsants Humans Membrane Glycoproteins Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Nerve Tissue Proteins Piracetam Protein Binding Protein Structure, Secondary Sequence Homology, Amino Acid 10.1371/journal.pone.0116589 PLoS ONE 10 2 e0116589 2019-11-07T05:01:41Z 2019-11-07T05:01:41Z 2015 Article Lee J., Daniels V., Sands Z.A., Lebon F., Shi J., Biggin P.C., Verma C. (2015). Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis. PLoS ONE 10 (2) : e0116589. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0116589 19326203 https://scholarbank.nus.edu.sg/handle/10635/161744 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101 |
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carrier proteins and binding proteins etiracetam radioligand SV2A protein ucb 30889 unclassified drug anticonvulsive agent etiracetam membrane protein nerve protein piracetam protein binding SV2A protein, human amino acid sequence Article binding site controlled study drug protein binding drug structure human human cell hydrophobicity ligand binding molecular dynamics nonhuman protein conformation radioassay sequence alignment sequence analysis site directed mutagenesis structural homology analogs and derivatives chemistry genetics metabolism molecular genetics protein secondary structure sequence homology Mus Amino Acid Sequence Anticonvulsants Humans Membrane Glycoproteins Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Nerve Tissue Proteins Piracetam Protein Binding Protein Structure, Secondary Sequence Homology, Amino Acid |
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carrier proteins and binding proteins etiracetam radioligand SV2A protein ucb 30889 unclassified drug anticonvulsive agent etiracetam membrane protein nerve protein piracetam protein binding SV2A protein, human amino acid sequence Article binding site controlled study drug protein binding drug structure human human cell hydrophobicity ligand binding molecular dynamics nonhuman protein conformation radioassay sequence alignment sequence analysis site directed mutagenesis structural homology analogs and derivatives chemistry genetics metabolism molecular genetics protein secondary structure sequence homology Mus Amino Acid Sequence Anticonvulsants Humans Membrane Glycoproteins Molecular Dynamics Simulation Molecular Sequence Data Mutagenesis, Site-Directed Nerve Tissue Proteins Piracetam Protein Binding Protein Structure, Secondary Sequence Homology, Amino Acid Lee J. Daniels V. Sands Z.A. Lebon F. Shi J. Biggin P.C. Verma C. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| description |
10.1371/journal.pone.0116589 |
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BIOLOGY |
| author_facet |
BIOLOGY Lee J. Daniels V. Sands Z.A. Lebon F. Shi J. Biggin P.C. Verma C. |
| format |
Article |
| author |
Lee J. Daniels V. Sands Z.A. Lebon F. Shi J. Biggin P.C. Verma C. |
| author_sort |
Lee J. |
| title |
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| title_short |
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| title_full |
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| title_fullStr |
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| title_full_unstemmed |
Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| title_sort |
exploring the interaction of sv2a with racetams using homology modelling, molecular dynamics and site-directed mutagenesis |
| publishDate |
2019 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/161744 |
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1821217200564862976 |