No difference in the rate of change in telomere length or telomerase activity in HIV-Infected patients after three years of darunavir/Ritonavir with and without nucleoside analogues in the monet trial

• Main Authors: Solomon A., Tennakoon S., Leeansyah E., Arribas J., Hill A., Van Delft Y., Moecklinghoff C., Lewin S.R.
• Other Authors: NUSHS PROJECT
• Format: Article
• Published: 2019
• Subjects: darunavir plus ritonavir; virus RNA; anti human immunodeficiency virus agent; darunavir; nucleoside; ritonavir; sulfonamide; telomerase; adult; age; Article; controlled clinical trial; controlled study; drug effect; female; human; human cell; Human immunodeficiency virus infection; major clinical study; male; monotherapy; peripheral blood mononuclear cell; randomized controlled trial; real time polymerase chain reaction; telomere; telomere length; telomere shortening; treatment duration; chemistry; clinical trial; drug combination; drug effects; genetics; HIV Infections; Human immunodeficiency virus 1; metabolism; middle aged; mononuclear cell; pathology; virology; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV-1; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Nucleosides; Ritonavir; RNA, Viral; Sulfonamides; Telomerase; Telomere
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161761
• Institution: National University of Singapore

10.1371/journal.pone.0109718