Chemotherapy-induced monoamine oxidase expression in prostate carcinoma functions as a cytoprotective resistance enzyme and associates with clinical outcomes

• Main Authors: Gordon R.R., Wu M., Huang C.-Y., Harris W.P., Sim H.G., Lucas J.M., Coleman I., Higano C.S., Gulati R., True L.D., Vessella R., Lange P.H., Garzotto M., Beer T.M., Nelson P.S.
• Other Authors: SURGERY
• Format: Article
• Published: 2019
• Subjects: amine oxidase (flavin containing) isoenzyme A; clorgyline; docetaxel; hypoxia inducible factor 1alpha; mitoxantrone; amine oxidase (flavin containing); antineoplastic agent; HIF1A protein, human; monoamine oxidase A, human; taxoid; tumor protein; animal experiment; animal model; animal tissue; apoptosis; Article; cancer adjuvant therapy; cancer recurrence; cell survival; controlled clinical trial; controlled study; drug cytotoxicity; drug dose escalation; drug effect; drug potentiation; drug resistance; drug response; enzyme activity; gene expression; gene identification; genetic transcription; human; human cell; human tissue; in vitro study; in vivo study; major clinical study; male; mouse; multiple cycle treatment; nonhuman; phase 1 clinical trial; phase 2 clinical trial; prostate carcinoma; prostatectomy; protein expression; treatment outcome; adult; animal; biosynthesis; clinical trial; drug effects; enzymology; gene expression regulation; metabolism; middle aged; pathology; Prostatic Neoplasms; SCID mouse; tumor cell line; Adult; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; Drug Resistance; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, SCID; Middle Aged; Mitoxantrone; Monoamine Oxidase; Neoplasm Proteins; Prostatectomy; Taxoids
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161775
• Institution: National University of Singapore

10.1371/journal.pone.0104271