Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion

• Main Authors: Gustavsson N., Wang X., Wang Y., Seah T., Xu J., Radda G.K., Südhof T.C., Han W.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: calcium ion; glucose; insulin; synaptotagmin; synaptotagmin 9; unclassified drug; calcium; animal tissue; article; body weight; calcium signaling; controlled study; exocytosis; gene deletion; glucose blood level; glucose homeostasis; glucose tolerance; in vivo study; insulin blood level; insulin release; isolated pancreas islet; mouse; nonhuman; animal; cell membrane; cell membrane potential; drug effect; electric capacitance; electron microscopy; female; genetics; glucose tolerance test; homeostasis; male; metabolism; mouse mutant; nerve cell; pancreas islet; pancreas islet beta cell; patch clamp; physiology; secretion; ultrastructure; Mus; Animals; Body Weight; Calcium; Cell Membrane; Electric Capacitance; Exocytosis; Female; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Membrane Potentials; Mice; Mice, Knockout; Microscopy, Electron; Neurons; Patch-Clamp Techniques; Synaptotagmins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161797
• Institution: National University of Singapore

10.1371/journal.pone.0015414