Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells

• Main Authors: Wang M., Bai J., Chen W.N., Ching C.B.
• Other Authors: TEMASEK LABORATORIES
• Format: Article
• Published: 2019
• Subjects: calcium ion; carvedilol; inositol; myristic acid; palmitic acid; pyroglutamic acid; serine; threonine; alanine; beta adrenergic receptor blocking agent; calcium; carbazole derivative; propanolamine derivative; article; calcium cell level; cell line; cell metabolism; controlled study; drug effect; in vitro study; mass fragmentography; metabolite; metabolomics; smooth muscle fiber; vascular smooth muscle; animal; chemistry; cytology; intracellular space; metabolism; metabolome; methodology; principal component analysis; rat; stereoisomerism; Adrenergic beta-Antagonists; Alanine; Animals; Calcium; Carbazoles; Cell Line; Gas Chromatography-Mass Spectrometry; Intracellular Space; Metabolome; Metabolomics; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Principal Component Analysis; Propanolamines; Rats; Stereoisomerism
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161798
• Institution: National University of Singapore

10.1371/journal.pone.0015441