Matched sizes of activating and inhibitory receptor ligand pairs are required for optimal signal integration by human natural killer cells

• Main Authors: Köhler K., Xiong S., Brzostek J., Mehrabi M., Eissmann P., Harrison A., Cordoba S.-P., Oddos S., Miloserdov V., Gould K., Burroughs N.J., van der Merwe P.A., Davis D.M.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: 2019
• Subjects: carrier protein; HLA C antigen; killer cell immunoglobulin like receptor 2DL1; natural killer cell receptor NKG2D; protein mica; unclassified drug; HLA antigen class 1; hybrid protein; KIR2DL1 protein, human; KLRK1 protein, human; ligand; MHC class I related chain A; MHC class I-related chain A; natural killer cell lectin like receptor subfamily K; photoprotein; animal cell; article; cell activation; cell contact; complex formation; controlled study; human; human cell; immunological synapse; lymphocyte activation; mouse; natural killer cell; nonhuman; protein binding; protein localization; RNA translation; signal transduction; amino acid sequence; cell line; confocal microscopy; genetics; metabolism; molecular genetics; Amino Acid Sequence; Cell Line; Histocompatibility Antigens Class I; HLA-C Antigens; Humans; Killer Cells, Natural; Ligands; Luminescent Proteins; Lymphocyte Activation; Microscopy, Confocal; Molecular Sequence Data; NK Cell Lectin-Like Receptor Subfamily K; Protein Binding; Receptors, KIR2DL1; Recombinant Fusion Proteins; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161801
• Institution: National University of Singapore

10.1371/journal.pone.0015374