HAMLET interacts with lipid membranes and perturbs their structure and integrity

• Main Authors: Mossberg A.-K., Puchades M., Halskau Ø., Baumann A., Lanekoff I., Chao Y., Martinez A., Svanborg C., Karlsson R.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: alanine; cysteine; fatty acid; membrane protein; protein hamlet; unclassified drug; lactalbumin; membrane lipid; oleic acid; article; binding affinity; bioaccumulation; fluorescence; human; human cell; internalization; lipid bilayer; lipid composition; lipid membrane; lipid vesicle; membrane fluidity; membrane structure; membrane vesicle; morphology; pH; protein lipid interaction; surface plasmon resonance; tumor cell; animal; apoptosis; binding competition; cell membrane; cell strain; chemistry; confocal microscopy; genetics; hamster; kinetics; metabolism; mutation; protein folding; rat; tumor cell line; Animals; Apoptosis; Binding, Competitive; Cell Line, Tumor; Cell Membrane; Cricetinae; Humans; Hydrogen-Ion Concentration; Kinetics; Lactalbumin; Lipid Bilayers; Membrane Lipids; Membrane Microdomains; Microscopy, Confocal; Mutation; Oleic Acid; PC12 Cells; Protein Folding; Rats; Surface Plasmon Resonance
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161816
• Institution: National University of Singapore

10.1371/journal.pone.0009384