A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells

• Main Authors: Song J., Duncan M.J., Li G., Chan C., Grady R., Stapleton A., Abraham S.N.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: adenylate cyclase; cyclic AMP; cyclic AMP responsive element binding protein binding protein; cytokine; immunoglobulin enhancer binding protein; interleukin 6; lipopolysaccharide; toll like receptor 4; transcription factor; bacterial RNA; calcium; CREBBP protein, human; TLR4 protein, human; unclassified drug; article; bladder epithelium; calcium cell level; cell motility; controlled study; epithelium cell; Escherichia coli; human; human cell; nonhuman; protein analysis; protein expression; protein phosphorylation; protein secretion; signal transduction; bladder; cytology; Enterobacter infection; fimbria; genetics; immunology; metabolism; microbiology; phosphorylation; Negibacteria; Adenylate Cyclase; Calcium; CREB-Binding Protein; Cyclic AMP; Epithelial Cells; Escherichia coli Infections; Fimbriae, Bacterial; Humans; Interleukin-6; Lipopolysaccharides; NF-kappa B; Phosphorylation; RNA, Bacterial; Signal Transduction; Toll-Like Receptor 4; Urinary Bladder
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161867
• Institution: National University of Singapore

10.1371/journal.ppat.0030060