Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

10.1371/journal.pgen.1006327

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Bibliographic Details
Main Authors:	Jakobsdottir J., van der Lee S.J., Bis J.C., Chouraki V., Li-Kroeger D., Yamamoto S., Grove M.L., Naj A., Vronskaya M., Salazar J.L., DeStefano A.L., Brody J.A., Smith A.V., Amin N., Sims R., Ibrahim-Verbaas C.A., Choi S.-H., Satizabal C.L., Lopez O.L., Beiser A., Ikram M.A., Garcia M.E., Hayward C., Varga T.V., Ripatti S., Franks P.W., Hallmans G., Rolandsson O., Jansson J.-H., Porteous D.J., Salomaa V., Eiriksdottir G., Rice K.M., Bellen H.J., Levy D., Uitterlinden A.G., Emilsson V., Rotter J.I., Aspelund T., O?Donnell C.J., Fitzpatrick A.L., Launer L.J., Hofman A., Wang L.-S., Williams J., Schellenberg G.D., Boerwinkle E., Psaty B.M., Seshadri S.
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	2019
Subjects:	amyloid beta protein apolipoprotein E membrane protein Notch receptor presenilin protein SKAP2 protein TM2D3 unclassified drug Amx protein, Drosophila amyloid precursor protein ApoE protein, human Drosophila protein signal peptide src kinase associated phosphoprotein 2 TM2D1 protein, human tropomyosin aged Alzheimer disease Article chromosome 15q controlled study ethnic difference exome female gene gene mutation genetic analysis genetic association genetic susceptibility genetic variability human Icelander major clinical study male molecular pathology nonhuman population based case control study protein structure signal transduction single nucleotide polymorphism TM2D3 gene allele animal Caucasian Drosophila melanogaster genetics genome-wide association study genomics Iceland mutation onset age pathology phenotype Age of Onset Aged Alleles Alzheimer Disease Amyloid beta-Protein Precursor Animals Apolipoproteins E Drosophila Proteins European Continental Ancestry Group Exome Female Genome-Wide Association Study Genomics Humans Intracellular Signaling Peptides and Proteins Male Membrane Proteins Mutation Phenotype Receptors, Notch Tropomyosin
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161904
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/161904