Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

• Main Authors: Verma S.S., Cooke Bailey J.N., Lucas A., Bradford Y., Linneman J.G., Hauser M.A., Pasquale L.R., Peissig P.L., Brilliant M.H., McCarty C.A., Haines J.L., Wiggs J.L., Vrabec T.R., Tromp G., Ritchie M.D., Bickel J., Chandler A., Holm I., Kohane I., Manzi S., Markianos K., Palmer N., Perry C., Savova G., Wolf W., Wong Kong S., Antommaria A., Cobb B., Harley J., Hutton J., Lingren T., Lynch J., Marsolo K., Myers M., Namjou B., Prows C., Solti I., Vinks S., Wagner M., Abrams D., Almoguera B., Chiavacci R., Connolly J., Devoto M., Hakonarson H., Keating B., Kim C., Mentch F., Qui H., Sleiman P., Tian L., Vazquez L., Bartko B., Bock J., Borthwick K., Carey D., Colonie R., Elston R., Faucett A., Fetterolf S., Gerhard G., Kuivaniemi H., Ledbetter D., Lipsky E., Pendergrass S., Sundaresan A., Smelser D., Williams J., Williams M., Wood C., Albrecht J., Carlson C., Carrell D., Crane P., Cronkite D., Crosslin D., Davis C., Ehrlich K., Fullterton M., Gallego C., Gordon A., Grafton J., Hansen K., Hartzler A., Jarvik G., Larson E., Leppig K., Mukherjee S., Ralston J., Scrol A., Tarczy-Hornoch P., Trinidad S., Bielinski S., Bruce K., Chute C., De Andrade M., Jouni H., Heit J., Isseh I., Koenig B., Kullo I., Li D., McCormick J., Pathak J., Russell J., Schultz C., Vitek C., Wussow L., Sharp R., Olson A., Chandra H., Armstrong G., Berg R., Brautbar A., Brilliant M., Finamore J., Frost N., Hall M., He M., Kitchner T., Lin S., Linneman J., Peissig P., Shefali S., Strenn R., Weichelt B., Bagiella E., Bottinger E., Dieterich D., Ellis S., Ferryman K., Friedman C., Friedman S., Galarneau G., Gomez A., Gottesman O., Hulot J.S., Horowitz C., Hripcsak G., Kannry J., Kenny E., Keppel Y., Lin J., Lotay V., Mejia A., Nadukuru R., Peter I., Rhodes R., Sanderson S., Scott S., Ullman T., Weijia Z., Weng C., Zinberg R., Armstrong L., Aufox S., Baker D., Cameron K., Chisholm R., Christensen C., Greenland P., Hayes G., Heathcote M., Kho A., Lowe B., Jackson K., Pacheco J., Pan V., Persell S., Rasmussen L., Rasmussen-Torvik L., Smith M., Starren J., Thompson W., Wicklund C., Brothers K., Chen L., Clayton E., Cowan J., Crawford D., Denny J., Edwards T., Harris P., Garrison N., Malin B., McGregor T., Peterson J., Roden D., Speltz P., Stallings S., Stroud M., Velez D., Van Driest S., Wilke R., Basford M., Claar M.B., Hardebeck A., Kirby J., Ritchie M., Setia S., Kaufman D., Li R., Manolio T., Allingham R.R., Budenz D.L., Kang J.H., Gaasterland D., Gaasterland T., Lee R.K., Lichter P.R., Liu Y., Moroi S.E., Realini A., Ritch R., Richards J.E., Schuman J.S., Scott B., Singh K., Vollrath D., Weinreb R.N., Wollstein G., Yaspan B.L., Yoneyama S., Zack D.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: Article; case control study; electronic medical record; epistasis; gene expression; gene interaction; gene replication; genetic association; genetic model; genetic risk; genetic susceptibility; genetic trait; genetic variability; genome-wide association study; heritability; human; information processing; open angle glaucoma; phenotype; replication study; single nucleotide polymorphism; trabecular meshwork; female; genetics; male; Case-Control Studies; Epistasis, Genetic; Female; Genome-Wide Association Study; Glaucoma, Open-Angle; Humans; Male; Phenotype; Polymorphism, Single Nucleotide
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161906
• Institution: National University of Singapore

10.1371/journal.pgen.1006186