Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

10.1371/journal.pmed.1002105

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Main Authors:	Guo Y., Warren Andersen S., Shu X.-O., Michailidou K., Bolla M.K., Wang Q., Garcia-Closas M., Milne R.L., Schmidt M.K., Chang-Claude J., Dunning A., Whittemore A.S., Winqvist R., Zhao H., Zhao S., Hall P., Simard J., Kraft P., Pharoah P., Hunter D., Easton D.F., Bojesen S.E., Zheng W., Ahsan H., Aittomäki K., Andrulis I.L., Anton-Culver H., Arndt V., Beckmann M.W., Beeghly-Fadiel A., Benitez J., Bogdanova N.V., Bonanni B., Børresen-Dale A.-L., Brand J., Brauch H., Brenner H., Brüning T., Burwinkel B., Casey G., Chenevix-Trench G., Couch F.J., Cox A., Cross S.S., Czene K., Devilee P., Dörk T., Dumont M., Fasching P.A., Figueroa J., Flesch-Janys D., Fletcher O., Flyger H., Fostira F., Gammon M., Giles G.G., Guénel P., Haiman C.A., Hamann U., Hooning M.J., Hopper J.L., Jakubowska A., Jasmine F., Jenkins M., John E.M., Johnson N., Jones M.E., Kabisch M., Kibriya M., Knight J.A., Koppert L.B., Kosma V.-M., Kristensen V., Le Marchand L., Lee E., Li J., Lindblom A., Luben R., Lubinski J., Malone K.E., Mannermaa A., Margolin S., Marme F., McLean C., Meijers-Heijboer H., Meindl A., Neuhausen S.L., Nevanlinna H., Neven P., Olson J.E., Perez J.I.A., Perkins B., Peterlongo P., Phillips K.-A., Pylkäs K., Rudolph A., Santella R., Sawyer E.J., Schmutzler R.K., Seynaeve C., Shah M., Shrubsole M.J., Southey M.C., Swerdlow A.J., Toland A.E., Tomlinson I., Torres D., Truong T., Ursin G., Van Der Luijt R.B., Verhoef S.
Other Authors:	SURGERY
Format:	Article
Published:	2019
Subjects:	adult aged Article body mass breast cancer disease association environmental factor female gene frequency genetic heterogeneity genotyping technique human logistic regression analysis major clinical study Mendelian randomization analysis middle aged premenopause single nucleotide polymorphism weight change young adult Breast Neoplasms Caucasian genetic predisposition genetics menopause risk factor statistical model statistics and numerical data Body Mass Index European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Mendelian Randomization Analysis Menopause Middle Aged Models, Statistical Polymorphism, Single Nucleotide Risk Factors
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161909
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Institution:	National University of Singapore

id	sg-nus-scholar.10635-161909
record_format	dspace
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adult aged Article body mass breast cancer disease association environmental factor female gene frequency genetic heterogeneity genotyping technique human logistic regression analysis major clinical study Mendelian randomization analysis middle aged premenopause single nucleotide polymorphism weight change young adult Breast Neoplasms Caucasian genetic predisposition genetics Mendelian randomization analysis menopause risk factor statistical model statistics and numerical data Body Mass Index Breast Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Mendelian Randomization Analysis Menopause Middle Aged Models, Statistical Polymorphism, Single Nucleotide Risk Factors
spellingShingle	adult aged Article body mass breast cancer disease association environmental factor female gene frequency genetic heterogeneity genotyping technique human logistic regression analysis major clinical study Mendelian randomization analysis middle aged premenopause single nucleotide polymorphism weight change young adult Breast Neoplasms Caucasian genetic predisposition genetics Mendelian randomization analysis menopause risk factor statistical model statistics and numerical data Body Mass Index Breast Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Mendelian Randomization Analysis Menopause Middle Aged Models, Statistical Polymorphism, Single Nucleotide Risk Factors Guo Y. Warren Andersen S. Shu X.-O. Michailidou K. Bolla M.K. Wang Q. Garcia-Closas M. Milne R.L. Schmidt M.K. Chang-Claude J. Dunning A. Whittemore A.S. Winqvist R. Zhao H. Zhao S. Hall P. Simard J. Kraft P. Pharoah P. Hunter D. Easton D.F. Bojesen S.E. Zheng W. Ahsan H. Aittomäki K. Andrulis I.L. Anton-Culver H. Arndt V. Beckmann M.W. Beeghly-Fadiel A. Benitez J. Bogdanova N.V. Bonanni B. Børresen-Dale A.-L. Brand J. Brauch H. Brenner H. Brüning T. Burwinkel B. Casey G. Chenevix-Trench G. Couch F.J. Cox A. Cross S.S. Czene K. Devilee P. Dörk T. Dumont M. Fasching P.A. Figueroa J. Flesch-Janys D. Fletcher O. Flyger H. Fostira F. Gammon M. Giles G.G. Guénel P. Haiman C.A. Hamann U. Hooning M.J. Hopper J.L. Jakubowska A. Jasmine F. Jenkins M. John E.M. Johnson N. Jones M.E. Kabisch M. Kibriya M. Knight J.A. Koppert L.B. Kosma V.-M. Kristensen V. Le Marchand L. Lee E. Li J. Lindblom A. Luben R. Lubinski J. Malone K.E. Mannermaa A. Margolin S. Marme F. McLean C. Meijers-Heijboer H. Meindl A. Neuhausen S.L. Nevanlinna H. Neven P. Olson J.E. Perez J.I.A. Perkins B. Peterlongo P. Phillips K.-A. Pylkäs K. Rudolph A. Santella R. Sawyer E.J. Schmutzler R.K. Seynaeve C. Shah M. Shrubsole M.J. Southey M.C. Swerdlow A.J. Toland A.E. Tomlinson I. Torres D. Truong T. Ursin G. Van Der Luijt R.B. Verhoef S. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
description	10.1371/journal.pmed.1002105
author2	SURGERY
author_facet	SURGERY Guo Y. Warren Andersen S. Shu X.-O. Michailidou K. Bolla M.K. Wang Q. Garcia-Closas M. Milne R.L. Schmidt M.K. Chang-Claude J. Dunning A. Whittemore A.S. Winqvist R. Zhao H. Zhao S. Hall P. Simard J. Kraft P. Pharoah P. Hunter D. Easton D.F. Bojesen S.E. Zheng W. Ahsan H. Aittomäki K. Andrulis I.L. Anton-Culver H. Arndt V. Beckmann M.W. Beeghly-Fadiel A. Benitez J. Bogdanova N.V. Bonanni B. Børresen-Dale A.-L. Brand J. Brauch H. Brenner H. Brüning T. Burwinkel B. Casey G. Chenevix-Trench G. Couch F.J. Cox A. Cross S.S. Czene K. Devilee P. Dörk T. Dumont M. Fasching P.A. Figueroa J. Flesch-Janys D. Fletcher O. Flyger H. Fostira F. Gammon M. Giles G.G. Guénel P. Haiman C.A. Hamann U. Hooning M.J. Hopper J.L. Jakubowska A. Jasmine F. Jenkins M. John E.M. Johnson N. Jones M.E. Kabisch M. Kibriya M. Knight J.A. Koppert L.B. Kosma V.-M. Kristensen V. Le Marchand L. Lee E. Li J. Lindblom A. Luben R. Lubinski J. Malone K.E. Mannermaa A. Margolin S. Marme F. McLean C. Meijers-Heijboer H. Meindl A. Neuhausen S.L. Nevanlinna H. Neven P. Olson J.E. Perez J.I.A. Perkins B. Peterlongo P. Phillips K.-A. Pylkäs K. Rudolph A. Santella R. Sawyer E.J. Schmutzler R.K. Seynaeve C. Shah M. Shrubsole M.J. Southey M.C. Swerdlow A.J. Toland A.E. Tomlinson I. Torres D. Truong T. Ursin G. Van Der Luijt R.B. Verhoef S.
format	Article
author	Guo Y. Warren Andersen S. Shu X.-O. Michailidou K. Bolla M.K. Wang Q. Garcia-Closas M. Milne R.L. Schmidt M.K. Chang-Claude J. Dunning A. Whittemore A.S. Winqvist R. Zhao H. Zhao S. Hall P. Simard J. Kraft P. Pharoah P. Hunter D. Easton D.F. Bojesen S.E. Zheng W. Ahsan H. Aittomäki K. Andrulis I.L. Anton-Culver H. Arndt V. Beckmann M.W. Beeghly-Fadiel A. Benitez J. Bogdanova N.V. Bonanni B. Børresen-Dale A.-L. Brand J. Brauch H. Brenner H. Brüning T. Burwinkel B. Casey G. Chenevix-Trench G. Couch F.J. Cox A. Cross S.S. Czene K. Devilee P. Dörk T. Dumont M. Fasching P.A. Figueroa J. Flesch-Janys D. Fletcher O. Flyger H. Fostira F. Gammon M. Giles G.G. Guénel P. Haiman C.A. Hamann U. Hooning M.J. Hopper J.L. Jakubowska A. Jasmine F. Jenkins M. John E.M. Johnson N. Jones M.E. Kabisch M. Kibriya M. Knight J.A. Koppert L.B. Kosma V.-M. Kristensen V. Le Marchand L. Lee E. Li J. Lindblom A. Luben R. Lubinski J. Malone K.E. Mannermaa A. Margolin S. Marme F. McLean C. Meijers-Heijboer H. Meindl A. Neuhausen S.L. Nevanlinna H. Neven P. Olson J.E. Perez J.I.A. Perkins B. Peterlongo P. Phillips K.-A. Pylkäs K. Rudolph A. Santella R. Sawyer E.J. Schmutzler R.K. Seynaeve C. Shah M. Shrubsole M.J. Southey M.C. Swerdlow A.J. Toland A.E. Tomlinson I. Torres D. Truong T. Ursin G. Van Der Luijt R.B. Verhoef S.
author_sort	Guo Y.
title	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
title_short	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
title_full	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
title_fullStr	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
title_full_unstemmed	Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
title_sort	genetically predicted body mass index and breast cancer risk: mendelian randomization analyses of data from 145,000 women of european descent
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161909
_version_	1821200086985605120
spelling	sg-nus-scholar.10635-1619092024-11-10T21:35:48Z Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent Guo Y. Warren Andersen S. Shu X.-O. Michailidou K. Bolla M.K. Wang Q. Garcia-Closas M. Milne R.L. Schmidt M.K. Chang-Claude J. Dunning A. Whittemore A.S. Winqvist R. Zhao H. Zhao S. Hall P. Simard J. Kraft P. Pharoah P. Hunter D. Easton D.F. Bojesen S.E. Zheng W. Ahsan H. Aittomäki K. Andrulis I.L. Anton-Culver H. Arndt V. Beckmann M.W. Beeghly-Fadiel A. Benitez J. Bogdanova N.V. Bonanni B. Børresen-Dale A.-L. Brand J. Brauch H. Brenner H. Brüning T. Burwinkel B. Casey G. Chenevix-Trench G. Couch F.J. Cox A. Cross S.S. Czene K. Devilee P. Dörk T. Dumont M. Fasching P.A. Figueroa J. Flesch-Janys D. Fletcher O. Flyger H. Fostira F. Gammon M. Giles G.G. Guénel P. Haiman C.A. Hamann U. Hooning M.J. Hopper J.L. Jakubowska A. Jasmine F. Jenkins M. John E.M. Johnson N. Jones M.E. Kabisch M. Kibriya M. Knight J.A. Koppert L.B. Kosma V.-M. Kristensen V. Le Marchand L. Lee E. Li J. Lindblom A. Luben R. Lubinski J. Malone K.E. Mannermaa A. Margolin S. Marme F. McLean C. Meijers-Heijboer H. Meindl A. Neuhausen S.L. Nevanlinna H. Neven P. Olson J.E. Perez J.I.A. Perkins B. Peterlongo P. Phillips K.-A. Pylkäs K. Rudolph A. Santella R. Sawyer E.J. Schmutzler R.K. Seynaeve C. Shah M. Shrubsole M.J. Southey M.C. Swerdlow A.J. Toland A.E. Tomlinson I. Torres D. Truong T. Ursin G. Van Der Luijt R.B. Verhoef S. SURGERY adult aged Article body mass breast cancer disease association environmental factor female gene frequency genetic heterogeneity genotyping technique human logistic regression analysis major clinical study Mendelian randomization analysis middle aged premenopause single nucleotide polymorphism weight change young adult Breast Neoplasms Caucasian genetic predisposition genetics Mendelian randomization analysis menopause risk factor statistical model statistics and numerical data Body Mass Index Breast Neoplasms European Continental Ancestry Group Female Genetic Predisposition to Disease Humans Mendelian Randomization Analysis Menopause Middle Aged Models, Statistical Polymorphism, Single Nucleotide Risk Factors 10.1371/journal.pmed.1002105 PLoS Medicine 13 8 e1002105 2019-11-08T06:47:48Z 2019-11-08T06:47:48Z 2016 Article Guo Y., Warren Andersen S., Shu X.-O., Michailidou K., Bolla M.K., Wang Q., Garcia-Closas M., Milne R.L., Schmidt M.K., Chang-Claude J., Dunning A., Whittemore A.S., Winqvist R., Zhao H., Zhao S., Hall P., Simard J., Kraft P., Pharoah P., Hunter D., Easton D.F., Bojesen S.E., Zheng W., Ahsan H., Aittomäki K., Andrulis I.L., Anton-Culver H., Arndt V., Beckmann M.W., Beeghly-Fadiel A., Benitez J., Bogdanova N.V., Bonanni B., Børresen-Dale A.-L., Brand J., Brauch H., Brenner H., Brüning T., Burwinkel B., Casey G., Chenevix-Trench G., Couch F.J., Cox A., Cross S.S., Czene K., Devilee P., Dörk T., Dumont M., Fasching P.A., Figueroa J., Flesch-Janys D., Fletcher O., Flyger H., Fostira F., Gammon M., Giles G.G., Guénel P., Haiman C.A., Hamann U., Hooning M.J., Hopper J.L., Jakubowska A., Jasmine F., Jenkins M., John E.M., Johnson N., Jones M.E., Kabisch M., Kibriya M., Knight J.A., Koppert L.B., Kosma V.-M., Kristensen V., Le Marchand L., Lee E., Li J., Lindblom A., Luben R., Lubinski J., Malone K.E., Mannermaa A., Margolin S., Marme F., McLean C., Meijers-Heijboer H., Meindl A., Neuhausen S.L., Nevanlinna H., Neven P., Olson J.E., Perez J.I.A., Perkins B., Peterlongo P., Phillips K.-A., Pylkäs K., Rudolph A., Santella R., Sawyer E.J., Schmutzler R.K., Seynaeve C., Shah M., Shrubsole M.J., Southey M.C., Swerdlow A.J., Toland A.E., Tomlinson I., Torres D., Truong T., Ursin G., Van Der Luijt R.B., Verhoef S. (2016). Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. PLoS Medicine 13 (8) : e1002105. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pmed.1002105 15491277 https://scholarbank.nus.edu.sg/handle/10635/161909 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

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