Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection

• Main Authors: Tan G.S., Leon P.E., Albrecht R.A., Margine I., Hirsh A., Bahl J., Krammer F.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Published: 2019
• Subjects: Fc receptor; hemagglutinin; monoclonal antibody; neutralizing antibody; virus vaccine; hemagglutinin, avian influenza A virus; influenza vaccine; Influenza virus hemagglutinin; virus antibody; virus antigen; animal experiment; antibody titer; antigen binding; Article; binding kinetics; controlled study; enzyme linked immunosorbent assay; epitope mapping; female; flow cytometry; genetic transfection; hemagglutination inhibition; Influenza A virus (H7N9); LD50; mouse; nonhuman; protein expression; protein purification; transactivation assay; Western blotting; animal; Bagg albino mouse; disease model; human; immunology; orthomyxovirus infection; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Antigens, Viral; Blotting, Western; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Flow Cytometry; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A Virus, H7N9 Subtype; Influenza Vaccines; Mice; Mice, Inbred BALB C; Orthomyxoviridae Infections
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161916
• Institution: National University of Singapore

10.1371/journal.ppat.1005578