Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells

• Main Authors: Burrack K.S., Tan J.J.L., McCarthy M.K., Her Z., Berger J.N., Ng L.F.P., Morrison T.E.
• Other Authors: BIOCHEMISTRY
• Format: Article
• Published: 2019
• Subjects: alpha interferon; beta interferon; C reactive protein; gamma interferon inducible protein 10; interleukin 10; interleukin 6; Arg1 protein, mouse; arginase; arginase I, human; Alphavirus infection; animal cell; animal experiment; animal model; animal tissue; arthritogenic alphaviral infection; Article; bone marrow cell; controlled study; flow cytometry; gene expression; mouse; nonhuman; polymerase chain reaction; real time polymerase chain reaction; reverse transcription polymerase chain reaction; RNA isolation; T cell depletion; T lymphocyte; transcription regulation; virus immunity; virus isolation; virus load; Western blotting; adoptive transfer; animal; C57BL mouse; chikungunya; Chikungunya virus; human; immunology; lymphocyte activation; Ross River virus; Adoptive Transfer; Alphavirus Infections; Animals; Arginase; Blotting, Western; Chikungunya Fever; Flow Cytometry; Humans; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Myeloid Cells; Polymerase Chain Reaction; T-Lymphocytes; Viral Load
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161931
• Institution: National University of Singapore

10.1371/journal.ppat.1005191