Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis

• Main Authors: Maier L., Diard M., Sellin M.E., Chouffane E.-S., Trautwein-Weidner K., Periaswamy B., Slack E., Dolowschiak T., Stecher B., German Center for Infection Research (DZIF) Partner site Ludwig Maximilian University of Munich, Loverdo C., Regoes R.R.
• Other Authors: MEDICINE
• Format: Article
• Published: 2019
• Subjects: reduced nicotinamide adenine dinucleotide phosphate oxidase; streptomycin; antiinfective agent; bacterial protein; membrane protein; SPI-2 protein, Salmonella; Spi1 protein, Salmonella; animal experiment; animal model; animal tissue; Article; bacterial growth; bacterial load; bacterium mutant; cecum; colitis; controlled study; flow cytometry; genetic variability; granulocyte; immunofluorescence test; inflammation; intestine flora; liver; mathematical model; mouse; nonhuman; real time polymerase chain reaction; Salmonella typhimurium; spleen; animal; C57BL mouse; disease model; female; gastrointestinal tract; genetics; growth, development and aging; male; metabolism; microbiology; microflora; mutation; pathology; physiology; Salmonella enterica serovar Typhimurium; Salmonella Infections, Animal; theoretical model; Mus; Salmonella; Animals; Anti-Bacterial Agents; Bacterial Proteins; Cecum; Colitis; Disease Models, Animal; Female; Gastrointestinal Tract; Granulocytes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microbiota; Models, Theoretical; Mutation; Streptomycin
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161942
• Institution: National University of Singapore

10.1371/journal.ppat.1004557