Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses

10.1371/journal.ppat.1004065

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Main Authors:	Butler J., Hooper K.A., Petrie S., Lee R., Maurer-Stroh S., Reh L., Guarnaccia T., Baas C., Xue L., Vitesnik S., Leang S.-K., McVernon J., Kelso A., Barr I.G., McCaw J.M., Bloom J.D., Hurt A.C.
Other Authors:	BIOLOGICAL SCIENCES
Format:	Article
Published:	2019
Subjects:	DNA fragment oseltamivir virus sialidase antivirus agent NA protein, influenza A virus sialidase virus protein 2009 H1N1 influenza article clinical article clinical feature controlled study disease course disease transmission drug resistance enzyme activity enzyme inhibition assay gene amplification gene mutation human human cell in vitro study influenza mathematical model protein expression quantitative analysis reverse transcription polymerase chain reaction RNA extraction sequence analysis site directed mutagenesis virus replication amino acid substitution animal antagonists and inhibitors antiviral resistance dog ferret genetics Influenza virus A H1N1 Influenza, Human MDCK cell line missense mutation reproductive fitness Amino Acid Substitution Animals Antiviral Agents Dogs Drug Resistance, Viral Ferrets Genetic Fitness Humans Influenza A Virus, H1N1 Subtype Madin Darby Canine Kidney Cells Mutation, Missense Neuraminidase Oseltamivir Viral Proteins
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/161953
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1619532024-04-03T10:36:43Z Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses Butler J. Hooper K.A. Petrie S. Lee R. Maurer-Stroh S. Reh L. Guarnaccia T. Baas C. Xue L. Vitesnik S. Leang S.-K. McVernon J. Kelso A. Barr I.G. McCaw J.M. Bloom J.D. Hurt A.C. BIOLOGICAL SCIENCES DNA fragment oseltamivir virus sialidase antivirus agent NA protein, influenza A virus oseltamivir sialidase virus protein 2009 H1N1 influenza article clinical article clinical feature controlled study disease course disease transmission drug resistance enzyme activity enzyme inhibition assay gene amplification gene mutation human human cell in vitro study influenza mathematical model protein expression quantitative analysis reverse transcription polymerase chain reaction RNA extraction sequence analysis site directed mutagenesis virus replication amino acid substitution animal antagonists and inhibitors antiviral resistance dog ferret genetics Influenza virus A H1N1 Influenza, Human MDCK cell line missense mutation reproductive fitness Amino Acid Substitution Animals Antiviral Agents Dogs Drug Resistance, Viral Ferrets Genetic Fitness Humans Influenza A Virus, H1N1 Subtype Influenza, Human Madin Darby Canine Kidney Cells Mutation, Missense Neuraminidase Oseltamivir Viral Proteins 10.1371/journal.ppat.1004065 PLoS Pathogens 10 4 e1004065 2019-11-08T08:50:57Z 2019-11-08T08:50:57Z 2014 Article Butler J., Hooper K.A., Petrie S., Lee R., Maurer-Stroh S., Reh L., Guarnaccia T., Baas C., Xue L., Vitesnik S., Leang S.-K., McVernon J., Kelso A., Barr I.G., McCaw J.M., Bloom J.D., Hurt A.C. (2014). Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses. PLoS Pathogens 10 (4) : e1004065. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.ppat.1004065 15537366 https://scholarbank.nus.edu.sg/handle/10635/161953 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	DNA fragment oseltamivir virus sialidase antivirus agent NA protein, influenza A virus oseltamivir sialidase virus protein 2009 H1N1 influenza article clinical article clinical feature controlled study disease course disease transmission drug resistance enzyme activity enzyme inhibition assay gene amplification gene mutation human human cell in vitro study influenza mathematical model protein expression quantitative analysis reverse transcription polymerase chain reaction RNA extraction sequence analysis site directed mutagenesis virus replication amino acid substitution animal antagonists and inhibitors antiviral resistance dog ferret genetics Influenza virus A H1N1 Influenza, Human MDCK cell line missense mutation reproductive fitness Amino Acid Substitution Animals Antiviral Agents Dogs Drug Resistance, Viral Ferrets Genetic Fitness Humans Influenza A Virus, H1N1 Subtype Influenza, Human Madin Darby Canine Kidney Cells Mutation, Missense Neuraminidase Oseltamivir Viral Proteins
spellingShingle	DNA fragment oseltamivir virus sialidase antivirus agent NA protein, influenza A virus oseltamivir sialidase virus protein 2009 H1N1 influenza article clinical article clinical feature controlled study disease course disease transmission drug resistance enzyme activity enzyme inhibition assay gene amplification gene mutation human human cell in vitro study influenza mathematical model protein expression quantitative analysis reverse transcription polymerase chain reaction RNA extraction sequence analysis site directed mutagenesis virus replication amino acid substitution animal antagonists and inhibitors antiviral resistance dog ferret genetics Influenza virus A H1N1 Influenza, Human MDCK cell line missense mutation reproductive fitness Amino Acid Substitution Animals Antiviral Agents Dogs Drug Resistance, Viral Ferrets Genetic Fitness Humans Influenza A Virus, H1N1 Subtype Influenza, Human Madin Darby Canine Kidney Cells Mutation, Missense Neuraminidase Oseltamivir Viral Proteins Butler J. Hooper K.A. Petrie S. Lee R. Maurer-Stroh S. Reh L. Guarnaccia T. Baas C. Xue L. Vitesnik S. Leang S.-K. McVernon J. Kelso A. Barr I.G. McCaw J.M. Bloom J.D. Hurt A.C. Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
description	10.1371/journal.ppat.1004065
author2	BIOLOGICAL SCIENCES
author_facet	BIOLOGICAL SCIENCES Butler J. Hooper K.A. Petrie S. Lee R. Maurer-Stroh S. Reh L. Guarnaccia T. Baas C. Xue L. Vitesnik S. Leang S.-K. McVernon J. Kelso A. Barr I.G. McCaw J.M. Bloom J.D. Hurt A.C.
format	Article
author	Butler J. Hooper K.A. Petrie S. Lee R. Maurer-Stroh S. Reh L. Guarnaccia T. Baas C. Xue L. Vitesnik S. Leang S.-K. McVernon J. Kelso A. Barr I.G. McCaw J.M. Bloom J.D. Hurt A.C.
author_sort	Butler J.
title	Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
title_short	Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
title_full	Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
title_fullStr	Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
title_full_unstemmed	Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses
title_sort	estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant a(h1n1)pdm09 influenza viruses
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/161953
_version_	1795374125120749568

Estimating the Fitness Advantage Conferred by Permissive Neuraminidase Mutations in Recent Oseltamivir-Resistant A(H1N1)pdm09 Influenza Viruses

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