Human embryonic mesenchymal stem cell-derived conditioned medium rescues kidney function in rats with established chronic kidney disease

• Main Authors: van Koppen A., Joles J.A., van Balkom B.W.M., Lim S.K., de Kleijn D., Giles R.H., Verhaar M.C.
• Other Authors: SURGERY
• Format: Article
• Published: 2019
• Subjects: CXCL9 chemokine; interleukin 1 receptor blocking agent; macrophage inflammatory protein 1alpha; macrophage inflammatory protein 3alpha; mesenchymal stem cell derived conditioned medium; protective agent; RANTES; tissue inhibitor of metalloproteinase 1; unclassified drug; vasculotropin; angiogenesis; animal experiment; animal model; animal tissue; antihypertensive activity; article; chronic kidney disease; controlled study; cytokine production; DNA repair; embryonic stem cell; endothelium cell; exosome; glomerulosclerosis; glomerulus filtration rate; hypertension; inulin clearance; kidney plasma flow; male; mesenchymal stem cell; nephrectomy; nonhuman; proteinuria; rat; renal protection; salt intake; systolic blood pressure; wound closure; Animals; Blood Pressure; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Disease Progression; DNA Repair; Humans; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Mesenchymal Stromal Cells; Neovascularization, Physiologic; Podocytes; Rats; Rats, Inbred Lew; Renal Insufficiency, Chronic; Wound Healing
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161975
• Institution: National University of Singapore

10.1371/journal.pone.0038746