Myocardial structural alteration and systolic dysfunction in preclinical hypertrophic cardiomyopathy mutation carriers

• Main Authors: Yiu K.H., Atsma D.E., Delgado V., Ng A.C.T., Witkowski T.G., Ewe S.H., Auger D., Holman E.R., van Mil A.M., Breuning M.H., Tse H.F., Bax J.J., Schalij M.J., Marsan N.A.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; diuretic agent; myosin binding protein C; adult; article; calibration; cardiovascular risk; clinical article; controlled study; coronary artery disease; diabetes mellitus; electrocardiogram; female; gene mutation; heart ejection fraction; heart infarction; heart left ventricle; heart muscle; heart muscle revascularization; heart ventricle wall motion; heterozygote detection; human; hyperlipidemia; hypertension; hypertrophic cardiomyopathy; kidney dysfunction; male; phenotype; protein expression; reproducibility; sensitivity and specificity; smoking; systolic dysfunction; echocardiography; echography; genetics; heterozygote; middle aged; mutation; pathology; pathophysiology; physiology; prognosis; systole; Adult; Cardiomyopathy, Hypertrophic; Echocardiography; Female; Heterozygote; Humans; Male; Middle Aged; Mutation; Myocardium; Phenotype; Prognosis; Reproducibility of Results; Systole
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/161984
• Institution: National University of Singapore

10.1371/journal.pone.0036115