Effects of Sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948)

• Main Authors: Raut C.P., Boucher Y., Duda D.G., Morgan J.A., Quek R., Ancukiewicz M., Lahdenranta J., Eder J.P., Demetri G.D., Jain R.K.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: biological marker; placental growth factor; sorafenib; stromal cell derived factor 1alpha; vasculotropin; vasculotropin receptor 2; angiogenic protein; antineoplastic agent; benzenesulfonic acid derivative; protein kinase inhibitor; pyridine derivative; tumor marker; adult; advanced cancer; aged; alopecia; anorexia; article; blood vessel permeability; cancer patient; clinical article; continuous infusion; controlled study; dehydration; desquamation; diarrhea; disease course; drug efficacy; drug eruption; drug fever; erythema multiforme; erythrocyte count; fatigue; female; hand foot syndrome; hemoglobin blood level; human; human cell; human tissue; hypertension; leg pain; male; mouth pain; mucosa inflammation; myalgia; phase 2 clinical trial; protein blood level; protein synthesis inhibition; pruritus; side effect; skin toxicity; soft tissue sarcoma; stomatitis; thrombocyte; tissue pressure; tumor biopsy; tumor volume; blood; capillary permeability; clinical trial; drug effect; extracellular fluid; middle aged; pressure; salvage therapy; sarcoma; Adult; Aged; Aged, 80 and over; Angiogenic Proteins; Antineoplastic Agents; Benzenesulfonates; Capillary Permeability; Extracellular Fluid; Female; Humans; Male; Middle Aged; Pressure; Protein Kinase Inhibitors; Pyridines; Salvage Therapy; Sarcoma; Tumor Markers, Biological; Vascular Endothelial Growth Factors
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162003
• Institution: National University of Singapore

10.1371/journal.pone.0026331