TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells

10.1371/journal.pone.0023681

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Main Authors:	Mitra A., Kalayarasan S., Gupta V., Radha V.
Other Authors:	MECHANOBIOLOGY INSTITUTE
Format:	Article
Published:	2019
Subjects:	forskolin guanine nucleotide exchange factor guanine nucleotide exchange factor C3G non receptor protein tyrosine phosphatase 2 pervanadate phosphotyrosine somatomedin tyrosine unclassified drug vanadic acid mutant protein protein tyrosine kinase PTPN2 protein, human animal cell article binding assay carboxy terminal sequence complex formation controlled study embryo enzyme inactivation enzyme substrate Golgi complex human human cell in vitro study in vivo study nerve cell differentiation nerve fiber growth neuroblastoma neuroblastoma cell nonhuman nucleotide binding site oncogene src protein dephosphorylation protein expression protein function protein localization protein phosphorylation protein protein interaction cell differentiation cell strain HEK293 chemistry drug effect enzymology metabolism neurite pathology phosphorylation protein binding protein tertiary structure protein transport structure activity relation tumor cell line Cell Differentiation Cell Line, Tumor Forskolin Golgi Apparatus Guanine Nucleotide-Releasing Factor 2 HEK293 Cells Humans Mutant Proteins Neurites Neuroblastoma Phosphorylation Phosphotyrosine Protein Binding Protein Structure, Tertiary Protein Transport Protein Tyrosine Phosphatase, Non-Receptor Type 2 src-Family Kinases Structure-Activity Relationship Vanadates
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/162035
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1620352020-11-18T02:03:48Z TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells Mitra A. Kalayarasan S. Gupta V. Radha V. MECHANOBIOLOGY INSTITUTE forskolin guanine nucleotide exchange factor guanine nucleotide exchange factor C3G non receptor protein tyrosine phosphatase 2 pervanadate phosphotyrosine somatomedin tyrosine unclassified drug vanadic acid forskolin guanine nucleotide exchange factor mutant protein non receptor protein tyrosine phosphatase 2 phosphotyrosine protein tyrosine kinase PTPN2 protein, human vanadic acid animal cell article binding assay carboxy terminal sequence complex formation controlled study embryo enzyme inactivation enzyme substrate Golgi complex human human cell in vitro study in vivo study nerve cell differentiation nerve fiber growth neuroblastoma neuroblastoma cell nonhuman nucleotide binding site oncogene src protein dephosphorylation protein expression protein function protein localization protein phosphorylation protein protein interaction cell differentiation cell strain HEK293 chemistry drug effect enzymology metabolism neurite neuroblastoma pathology phosphorylation protein binding protein tertiary structure protein transport structure activity relation tumor cell line Cell Differentiation Cell Line, Tumor Forskolin Golgi Apparatus Guanine Nucleotide-Releasing Factor 2 HEK293 Cells Humans Mutant Proteins Neurites Neuroblastoma Phosphorylation Phosphotyrosine Protein Binding Protein Structure, Tertiary Protein Transport Protein Tyrosine Phosphatase, Non-Receptor Type 2 src-Family Kinases Structure-Activity Relationship Vanadates 10.1371/journal.pone.0023681 PLoS ONE 6 8 e23681 2019-11-11T08:38:23Z 2019-11-11T08:38:23Z 2011 Article Mitra A., Kalayarasan S., Gupta V., Radha V. (2011). TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells. PLoS ONE 6 (8) : e23681. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0023681 19326203 https://scholarbank.nus.edu.sg/handle/10635/162035 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20191101
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	forskolin guanine nucleotide exchange factor guanine nucleotide exchange factor C3G non receptor protein tyrosine phosphatase 2 pervanadate phosphotyrosine somatomedin tyrosine unclassified drug vanadic acid forskolin guanine nucleotide exchange factor mutant protein non receptor protein tyrosine phosphatase 2 phosphotyrosine protein tyrosine kinase PTPN2 protein, human vanadic acid animal cell article binding assay carboxy terminal sequence complex formation controlled study embryo enzyme inactivation enzyme substrate Golgi complex human human cell in vitro study in vivo study nerve cell differentiation nerve fiber growth neuroblastoma neuroblastoma cell nonhuman nucleotide binding site oncogene src protein dephosphorylation protein expression protein function protein localization protein phosphorylation protein protein interaction cell differentiation cell strain HEK293 chemistry drug effect enzymology metabolism neurite neuroblastoma pathology phosphorylation protein binding protein tertiary structure protein transport structure activity relation tumor cell line Cell Differentiation Cell Line, Tumor Forskolin Golgi Apparatus Guanine Nucleotide-Releasing Factor 2 HEK293 Cells Humans Mutant Proteins Neurites Neuroblastoma Phosphorylation Phosphotyrosine Protein Binding Protein Structure, Tertiary Protein Transport Protein Tyrosine Phosphatase, Non-Receptor Type 2 src-Family Kinases Structure-Activity Relationship Vanadates
spellingShingle	forskolin guanine nucleotide exchange factor guanine nucleotide exchange factor C3G non receptor protein tyrosine phosphatase 2 pervanadate phosphotyrosine somatomedin tyrosine unclassified drug vanadic acid forskolin guanine nucleotide exchange factor mutant protein non receptor protein tyrosine phosphatase 2 phosphotyrosine protein tyrosine kinase PTPN2 protein, human vanadic acid animal cell article binding assay carboxy terminal sequence complex formation controlled study embryo enzyme inactivation enzyme substrate Golgi complex human human cell in vitro study in vivo study nerve cell differentiation nerve fiber growth neuroblastoma neuroblastoma cell nonhuman nucleotide binding site oncogene src protein dephosphorylation protein expression protein function protein localization protein phosphorylation protein protein interaction cell differentiation cell strain HEK293 chemistry drug effect enzymology metabolism neurite neuroblastoma pathology phosphorylation protein binding protein tertiary structure protein transport structure activity relation tumor cell line Cell Differentiation Cell Line, Tumor Forskolin Golgi Apparatus Guanine Nucleotide-Releasing Factor 2 HEK293 Cells Humans Mutant Proteins Neurites Neuroblastoma Phosphorylation Phosphotyrosine Protein Binding Protein Structure, Tertiary Protein Transport Protein Tyrosine Phosphatase, Non-Receptor Type 2 src-Family Kinases Structure-Activity Relationship Vanadates Mitra A. Kalayarasan S. Gupta V. Radha V. TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
description	10.1371/journal.pone.0023681
author2	MECHANOBIOLOGY INSTITUTE
author_facet	MECHANOBIOLOGY INSTITUTE Mitra A. Kalayarasan S. Gupta V. Radha V.
format	Article
author	Mitra A. Kalayarasan S. Gupta V. Radha V.
author_sort	Mitra A.
title	TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
title_short	TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
title_full	TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
title_fullStr	TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
title_full_unstemmed	TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells
title_sort	tc-ptp dephosphorylates the guanine nucleotide exchange factor c3g (rapgef1) and negatively regulates differentiation of human neuroblastoma cells
publishDate	2019
url	https://scholarbank.nus.edu.sg/handle/10635/162035
_version_	1686108560973365248

TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells

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