HAMLET binding to ?-actinin facilitates tumor cell detachment

• Main Authors: Trulsson M., Yu H., Gisselsson L., Chao Y., Urbano A., Aits S., Mossberg A.-K., Svanborg C.
• Other Authors: DUKE-NUS MEDICAL SCHOOL
• Format: Article
• Published: 2019
• Subjects: alpha actinin; alpha actinin 1; alpha actinin 4; alpha lactalbumin; beta1 integrin; F actin; focal adhesion kinase 1; human alpha lactalbumin made lethal to tumor cell; ion channel; mitogen activated protein kinase 1; small interfering RNA; unclassified drug; actin; actinin; cell extract; focal adhesion kinase; HAMLET complex, human; lactalbumin; oleic acid; peptide; amino acid sequence; article; binding site; cell adhesion; cell proliferation; cell structure; cell survival; cell viability; controlled study; enzyme phosphorylation; human; human cell; immunoprecipitation; in vitro study; molecular mechanics; polyacrylamide gel electrophoresis; protein binding; protein cross linking; protein domain; protein expression; protein isolation; protein localization; protein protein interaction; signal transduction; tumor cell; biological model; cell death; chemical structure; chemistry; drug effect; enzymology; metabolism; molecular genetics; neoplasm; pathology; protein analysis; protein transport; tumor cell line; Actinin; Actins; Amino Acid Sequence; Antigens, CD29; Binding Sites; Cell Adhesion; Cell Death; Cell Extracts; Cell Line, Tumor; Cell Survival; Focal Adhesion Protein-Tyrosine Kinases; Humans; Lactalbumin; Models, Biological; Models, Molecular; Molecular Sequence Data; Neoplasms; Oleic Acids; Peptides; Protein Binding; Protein Interaction Mapping; Protein Transport; Signal Transduction
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162055
• Institution: National University of Singapore

10.1371/journal.pone.0017179