Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators

• Main Authors: Bai Z., Chai X.-R., Yoon M.J., Kim H.-J., Lo K.A., Zhang Z.-C., Xu D., Siang D.T.C., Walet A.C.E., Xu S.-H., Chia S.-Y., Chen P., Yang H., Ghosh S., Sun L.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: Public Library of Science 2020
• Subjects: adipocytokine; beta adrenergic receptor stimulating agent; CELF1 protein; cyclic AMP responsive element binding protein; long untranslated RNA; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma coactivator 1alpha; uncoupling protein 1; cyclic AMP; transcriptome; adipocyte; adipose tissue; animal cell; animal experiment; animal model; animal tissue; Article; binding site; cell differentiation; cell structure; citric acid cycle; cold exposure; controlled study; down regulation; energy expenditure; exercise intensity; fatty acid oxidation; gene expression; glycation; lipid storage; long term exposure; male; mouse; nonhuman; oxidative phosphorylation; promoter region; protein expression; protein RNA binding; respiratory chain; RNA sequence; signal transduction; tissue differentiation; upregulation; white adipose tissue; animal; C57BL mouse; energy metabolism; gene expression regulation; HEK293 cell line; human; metabolism; primary cell culture; Adipose Tissue; Animals; CELF1 Protein; Cell Differentiation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Energy Metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Primary Cell Culture; RNA, Long Noncoding; Signal Transduction; Transcriptome
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165372
• Institution: National University of Singapore

10.1371/journal.pbio.2002176