More Than 1,001 problems with protein domain databases: Transmembrane regions, signal peptides and the issue of sequence homology

• Main Authors: Wong W.-C., Maurer-Stroh S., Eisenhaber F.
• Other Authors: BIOLOGICAL SCIENCES
• Format: Article
• Published: Public Library of Science 2020
• Subjects: membrane protein; protein; signal peptide; amino acid sequence; article; calculation; controlled study; nonhuman; nucleotide sequence; prediction; protein analysis; protein database; protein folding; protein function; protein structure; scoring system; sequence alignment; sequence homology; animal; automated pattern recognition; biology; chemistry; classification; human; methodology; probability; protein tertiary structure; reproducibility; Animals; Computational Biology; Databases, Protein; Humans; Markov Chains; Membrane Proteins; Pattern Recognition, Automated; Protein Folding; Protein Sorting Signals; Protein Structure, Tertiary; Proteins; Reproducibility of Results; Sequence Homology, Amino Acid
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165418
• Institution: National University of Singapore

10.1371/journal.pcbi.1000867