Predictive factors for BRCA1 and BRCA2 genetic testing in an asian clinic-based population

• Main Authors: Wong E.S.Y., Shekar S., Chan C.H.T., Hong L.Z., Poon S.-Y., Silla T., Lin C., Kumar V., Davila S., Voorhoeve M., Thike A.A., Ho G.H., Yap Y.S., Tan P.H., Tan M.-H., Ang P., Lee A.S.G.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Public Library of Science 2020
• Subjects: BRCA1 protein; BRCA2 protein; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; adult; aged; Article; Asian; cancer classification; early cancer; estrogen receptor positive breast cancer; family history; female; gene sequence; genetic association; genetic screening; human; major clinical study; missense mutation; next generation sequencing; oncogene; onset age; ovary cancer; predictive value; progesterone receptor positive breast cancer; Sanger sequencing; triple negative breast cancer; tumor suppressor gene; age; Asian continental ancestry group; Breast Neoplasms; chi square distribution; dna mutational analysis; genetics; metabolism; middle aged; procedures; risk factor; Singapore; statistical model; statistics and numerical data; Triple Negative Breast Neoplasms; young adult; Adult; Age Factors; Aged; Asian Continental Ancestry Group; Chi-Square Distribution; DNA Mutational Analysis; Female; Genes, BRCA1; Genes, BRCA2; Genetic Testing; Humans; Logistic Models; Middle Aged; Mutation, Missense; Predictive Value of Tests; Receptors, Estrogen; Risk Factors; Young Adult
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165687
• Institution: National University of Singapore

10.1371/journal.pone.0134408