Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30

• Main Authors: Carnesecchi J., Malbouyres M., De Mets R., Balland M., Beauchef G., Vié K., Chamot C., Lionnet C., Ruggiero F., Vanacker J.-M.
• Other Authors: MECHANOBIOLOGY INSTITUTE
• Format: Article
• Published: Public Library of Science 2020
• Subjects: actin; cycloheximide; estradiol; estrogen; estrogen receptor; G protein coupled receptor 30; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylinositol 3 kinase; protein tyrosine kinase; short hairpin RNA; vinculin; 1,3 benzodioxole derivative; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline; estrogen receptor beta; G protein coupled receptor; GPER protein, human; MAPK1 protein, human; quinoline derivative; adult; Article; cell migration; cell proliferation; cell shape; cell structure; collagen synthesis; controlled study; cytoskeleton; cytoskeleton reorganization; enzyme activation; female; focal adhesion; human; human cell; inhibition kinetics; primary culture; protein expression; signal transduction; skin fibroblast; agonists; antagonists and inhibitors; dermis; drug effects; fibroblast; metabolism; Adult; Benzodioxoles; Dermis; Estradiol; Estrogen Receptor beta; Estrogens; Female; Fibroblasts; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/165701
• Institution: National University of Singapore

10.1371/journal.pone.0120672